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Стратегії синтезу [1,2,4]триазоло [1,5-a]піридин-8-карбонітрилів

Dmytro Khomenko1, Tetyana Shokol1, Roman Doroshchuk1, Ilona Raspertova1, Rostyslav Lampeka1, Yulian Volovenko1
Affiliation: 
1 Department of Chemistry, Taras Shevchenko National University of Kyiv, 64/13 Volodymyrska St., Kyiv 01601, Ukraine ilonabatyuk@gmail.com
DOI: 
https://doi.org/10.23939/chcht17.02.294
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Abstract: 
Конденсовані гетероциклічні сполуки, що містять 1,2,4-триазольний цикл, представляють інтерес для науковців у зв’язку з їхнім широким застосуванням як у синтетичній, так і в медичній хімії. У цьому огляді було вичерпно узагальнено методи синтезу [1,2,4]триазоло[1,5-a]піри¬дин-8-карбонітрилів та класифіковано за типами використовува-них реагентів: перетворення 8-заміщених [1,2,4]три-азоло[1,5-a]піридинів; синтези на основі функціоналізованих піридинів, що містять нітрильну групу; синтези на основі гетероциклізації 2-(1,2,4-триазол-5-іл)ацетонітрилів, включаючи циклоконденсації 2-(1,2,4-триазол-5-іл)ацетонітрилів з β-дикарбонільними сполуками та гетероциклізації 2-(1,2,4-триазол-5-іл)ацетонітрилів з α,β-ненасиченими нітрилами та естерами; циклоконденсації ациклічних реагентів, а саме похідних гідразину та заміщених метиленмалононітрилів або їхніх прекурсорів і рециклізацію солей оксадіазолопіридинію під дією аміаку або амінів.
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