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Одержання та визначення противірусної й антибактеріальної активності s-естерів 4-r-амінобензенетіосульфокислоти

Ewa Zaczynska1, Anna Czarny2, Оlena Karpenko3,4, Sofiya Vasylyuk4, Nataliya Monka4, Nataliya Stadnytska4, Liubov Fizer4, Olena Komarovska-Porokhnyavets4, Maciej Jaranowski5, Vira Lubenets4, Michał Zimecki1
Affiliation: 
1 Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Immunobiology, R. Weigla St. 12, 53-114 Wrocław, Poland 2 Department of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Immunobiology, R. Weigla St. 12, 53-114 Wrocław, Poland 3 Department of Physical Chemistry of Fossil Fuels of the Institute of Physical Organic Chemistry and Coal Chemistry named after L. М. Lytvynenko of the NAS of Ukraine, 3а Naukova St., 79060 Lviv, Ukraine 4 Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, 12 S. Bandery St., 79013 Lviv, Ukraine 5 Alpinus Chemia Sp. z o. o., 5 Garbary St., 86-050 Solec Kujawski, Poland  vlubenets@gmail.com
DOI: 
https://doi.org/10.23939/chcht17.02.315
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Abstract: 
Алкілуванням натрієвої солі 4-ацетиламіно¬бен-зентіосульфокислоти різними алкілувальними агентами та ацилюванням відповідних естерів 4-амінобензентіосуль¬фо-кислоти метакрилоїлхлоридом синтезовано ряд S-естерів 4-R-амінобензен¬тіо¬сульфокислот. Для одержання S-метил 4-(аце¬тиламіно)бен¬зенсульфонотіоату розроблено методику син¬тезу, яка відповідає основним принципам "зеленої хімії". Сту¬пінь цитотоксичності сполук оцінювали через визначення рос¬ту клітин А-549 колориметричним методом. Антибак-теріальну активність тіосульфо¬натів визначали в агаровому дифузійному тесті, а противірусну дію – за цитопатичним ефектом за значенням TCID50.
References: 

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