Obtaining and Determining Antiviral and Antibacterial Activity of S-Esters of 4-R-Aminobenzenethiosulfonic Acid
Affiliation:
1 Department of Experimental Therapy, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Immunobiology, R. Weigla St. 12, 53-114 Wrocław, Poland
2 Department of Immunology of Infectious Diseases, Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Laboratory of Immunobiology, R. Weigla St. 12, 53-114 Wrocław, Poland
3 Department of Physical Chemistry of Fossil Fuels of the Institute of Physical Organic Chemistry and Coal Chemistry named after L. М. Lytvynenko of the NAS of Ukraine, 3а Naukova St., 79060 Lviv, Ukraine
4 Department of Technology of Biologically Active Substances, Pharmacy & Biotechnology, Lviv National Polytechnic University, 12 S. Bandery St., 79013 Lviv, Ukraine
5 Alpinus Chemia Sp. z o. o., 5 Garbary St., 86-050 Solec Kujawski, Poland
vlubenets@gmail.com
DOI:
https://doi.org/10.23939/chcht17.02.315
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Abstract:
A number of S-esters of 4-R-aminobenzene¬thiosulfonic acids were synthesized via alkylation of the sodium salt of 4-acetylaminobenzenethiosulfonic acid with various alkylating agents and acylation of the corresponding esters of 4-aminobenzenethiosulfonic acid with metha-cryloyl chloride. For obtaining S-methyl 4-(acetyla-mino)benzenesulfonothioate, it was developed a synthetic technique corresponding to the basic principles of "green chemistry". The degree of compound cytotox-icity was measured by determining A-549 cell growth using colorimetric method. The antibacterial activity of the thiosulfonates was determined by the agar diffusion test and the antiviral action by their cytopathic effect at TCID50 value.
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