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Вплив твін 80 на стабільність і конформацію теломерної g-квадруплексної днк

Ismail A. Elhaty1
Affiliation: 
1 Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey iaeismail@gelisim.edu.tr
DOI: 
https://doi.org/10.23939/chcht17.03.567
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Abstract: 
G-квадруплексна ДНК утворюється в тело¬мері. Вона пригнічує фермент теломеразу, активний у більш ніж 85 % ракових клітин. У цій роботі було вивчено вплив Твін 80 на теломерну G-квадруплексну ДНК AGGG(TTAGGG)3 за допомогою спектроскопічної методики циркулярного дихроїзму. Отримані результати показали, що використання Твін 80 з те¬ломерним квадруплексом є безпечним за концентрації до 1,0 %.
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