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Effect of Tween 80 on the Stability and Conformation of Telomeric G-Quadruplex DNA

Ismail A. Elhaty1
Affiliation: 
1 Department of Nutrition and Dietetics, Faculty of Health Sciences, Istanbul Gelisim University, Istanbul, Turkey iaeismail@gelisim.edu.tr
DOI: 
https://doi.org/10.23939/chcht17.03.567
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PDF icon full_text.pdf588.16 KB
Abstract: 
G-quadruplex DNA is formed in telomer. It inhibits telomerase enzyme which is found active in more than 85 % of cancer cells. In this work, the effect of Tween 80 on telomeric G-quadruplex DNA, AGGG(TTAGGG)3 was studied using circular dichroism spectroscopic technique. The obtained results showed that using Tween 80 with telomeric quadruplex is safe up to less than 1.0 %.
References: 

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