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Синтез, характеристика і біологічна активність суміші лігандів (іміну бензидину та 1,10-фенантроліну) та йонів Fe(II), Co(II), Ni(II) та Cu(II)

Zainab M. Hassan1, Rawaa A. Alattar1, Suhad Kareem Abass1, Hayder Hamied Mihsen1, Zainab Fadhil Abbas2, Khalid A. Hussain2
Affiliation: 
1 Department of Chemistry, College of Science, University of Kerbala, Karbala, Iraq 2 Department of Biology, College of Science, University of Kerbala, Karbala, Iraq hayderalhmedat@gmail.com
DOI: 
https://doi.org/10.23939/chcht16.01.015
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Keywords:

Abstract: 
За реакцією первинного ліганду (іміну бензидину) (H2L) та вторинного ліганду (1,10-фенантролін) (L`) з йонами металів Fe(II), Co(II), Ni(II) та Cu(II) у мольному співвідношенні 1:2:2 синтезовані бінуклеарні металічні комплекси. За допомогою елементарного аналізу, FT-IR, UV-VIS, магнітної сприйнятливості, молярної провідності, 1H ЯМР та термогравіметричного аналізу TGA-DTA визначено характеристику комплексів. Показано, що комплекси з Fe(II), Co(II) і Ni(II) мають восьмигранну геометрію, тоді як комплекс з Cu(II) має квадратну площинну геометрію. Всі синтезовані комплекси стійкі і можуть зберігатися місяцями без суттєвих змін. З використанням дифузійних агарових пластинок проведено оцінку антибактеріальної активності одержаних сполук стосовно двох видів бактерій, грампозитивної та грамнегативної (Kelbsiella та Proteus). Встановлено, що бактерія Klebsiella є більш чутливою до цих сполук, ніж Proteus. Показано, що синтезовані сполуки мають більший вплив на бактерії у порівнянні з антибіотиком (Амікацин).
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