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Особливості взаємодії (бензо)імідазо[2,1-b][1,3]тіазинмезилатів з нуклеофільними реагентами

Nataliia Slyvka1, Lesya Saliyeva1, Mariia Litvinchuk2, Svitlana Shishkina3, Mykhailo Vovk2
Affiliation: 
1 Department of Organic Chemistry and Pharmacy, Lesya Ukrainka Volyn National University, Volya Ave. 13, Lutsk 43025, Ukraine 2 Department of Functional Heterocyclic Systems, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, Acad. Kuharya St. 5, Kyiv 02660, Ukraine 3 Department of X-ray Diffraction Study and Quantum Chemistry, SSI “Institute for Single Crystals”, National Academy of Sciences of Ukraine, Nauka Ave. 60, Kharkiv 61000, Ukraine slivka.natalia@vnu.edu.ua
DOI: 
https://doi.org/10.23939/chcht17.03.542
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Abstract: 
Вивчено особливості перебігу реакцій метан¬¬сульфопохідних (бенз)імідазо[2,1-b][1,3]тіазинів з рядом нукле¬офільних реагентів. Встановлено, що вони неселективно реа¬гують із калію тіоціанатом, утворюючи суміш тіо- та ізотіо¬ціа-натопохідних. У свою чергу, у результаті взаємодії з натрію азидом поряд із нуклеофільним заміщенням має місце конку-руюча реакція елімінування. Остання реалізується як домінуюча в реакції з натрію ціанідом. Методом рентгеноструктурного аналізу встановлено просторову будову одного з ізомерних про¬дуктів елімінування – 4H-бензо[4,5]імідазо[2,1-b][1,3]тіазину.
References: 

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