Synthesis and Properties of Phosphorus-Containing Pseudo-Poly(Amino Acid)sof Polyester Type Based on N-Derivatives of Glutaminic Acid

Anna Stasiuk1, Nataliia Fihurka1, Vasyl Vlizlo2, Sofiia Prychak1, Dmytro Ostapiv3, Serhii Varvarenko1, Volodymyr Samaryk1
1Lviv Polytechnic National University, 12 S. Bandery St., Lviv 79013, Ukraine 2Stepan Gzhytskyi National University of Veterinary Medicine and Biotechnologies, 50 Pekarska St., Lviv79010, Ukraine 3Institute of Animal Biology NAAS, 38 V. Stusa St., Lviv 79034, Ukraine
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Poly(phosphoeter)s (PPE)s are a class of polymers possessing a high chemical functionality and biodegradability. Novel, glutamic acid based poly(phosphoeter)s were synthesized by the Steglich reaction. The developed synthetic approach allows controlling the composition and the structure of PPEs, and therefore their physical and colloidal properties. The studies on solubilization and cytotoxicity in vitro proved the potential of PPEs for drug delivery applications.

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