Синтез, антимікробні й обчислювальні дослідження нових похідних розгалужених азафенотіазинонів
Affiliation:
1Natural Science Unit, School of General Studies, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria
2Departmentof Pure and Industrial Chemistry, University of Nigeria, Nsukka, 410001, Enugu State, Nigeria
3Department of Chemistry, Gregory University, Uturu, Abia State, Nigeria
4Department of Chemistry, North Carolina State University, Raleigh, North Carolina, 27607, USA
efeturi.onoabedje@unn.edu.ng
DOI:
https://doi.org/10.23939/chcht17.04.786
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Abstract:
У процесі постійного пошуку нових медикаментозно активних нелінійних фенотіазинів синтезовано нові кутові похідні хлороазафенотіазинону за допомогою реакцій перехресного приєднання, каталізованих перехідними металами. Структурну будову синтезованих сполук встановлено за допомогою комбінованого спектроскопічного й елементного аналізу. Синтезовані сполуки були протестовані на антимікробну активність щодо ізолятів Bacillussubtilis, Staphylococcusaureus, Enterococusfaecalis, Escherichiacoli, Candidaalbican та Aspergillusniger методом конвекційного розведення в агаровому середовищі, і сполуки 5c та 8c виявили відмінну активність invitro проти деяких з досліджуваних мікроорганізмів. Дослідження insilico показало, що синтезовані сполуки мають перспективні фізико-хімічні властивості та добре вписуються в активний центр біотин-протеїнової лігази (BPL), утворюючи необхідні водневі зв'язки та гідрофобні взаємодії.
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