1. JCCT
  2. Ch&ChT Vol. 19, No. 1, 2025
  3. Synthesis and Anticancer Activity of Aminothiazole-Terminal Phenoxycompounds Hybrids and Their Analogs: A Short Review

Synthesis and Anticancer Activity of Aminothiazole-Terminal Phenoxycompounds Hybrids and Their Analogs: A Short Review

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Yuliia Matiichuk1, Orest Chemerys1, Borys Zimenkovsky1, Iryna Drapak1, Vasyl Matiychuk2
Affiliation: 
1 Danylo Halytsky Lviv National Medical University, 69 Pekarska, Lviv 79010, Ukraine 2 Ivan Franko National University of Lviv, 6 Kyryla and Mefodia St., Lviv 79005, Ukraine v_matiychuk@ukr.net
DOI: 
https://doi.org/10.23939/chcht19.01.061
AttachmentSize
PDF icon full_text.pdf529.23 KB
Keywords: 
2-aminothiazole
terminal phenoxy group
molecular hybridization
anticancer activity
Abstract: 
2-Aminothiazole and compounds with terminal phenoxy groups are privileged structures in medicinal chemistry. Compounds containing these two scaffolds are of interest for the design of new pharmaceuticals, particularly for treating malignant tumors. Hybridization, which is realized by combining both privileged fragments via the formation of covalent bonds, is a promising approach to finding lead compounds. The resulting conjugates can bind to a variety of receptors, and therefore, their synthesis and pharmacological screening is an actual task of modern medicinal chemistry. This review highlights the latest advances in the field of phenoxyalkylacylamino thiazoles and their analogs with anticancer potential, covering work published over the past two decades.
References: 

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