Synthesis and Selfassambling of Amphiphilic Oligoesters Based on Pyromellitic Acid
Affiliation:
1North Dakota State University, Dept. 2760,
P.O. Box 6050, Fargo, ND 58108-6050, USA; andriy.voronov@ndsu.edu
2Lviv Polytechnic National University;
12, S. Bandery str., 79013 Lviv, Ukraine; donchak@polynet.lviv.ua
DOI:
https://doi.org/10.23939/chcht10.02.159
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Abstract:
The method for synthesis of a new class of amphiphilic oligoesters of pyromellitic acid is developed. As hydrophilic fragments polyethylene glycols or polyethylene glycol mono methyl ethers were used, as lipophilic ones – primary fatty alcohols or cholesterol. The structure of the synthesized oligoesters was confirmed by IR- and PMR-spectroscopy. The oligoesters could solubilize water-insoluble substances, for example such effective antitumor lipophilic drug as curcumin. The high solubilization capacity of the OEPA assemblies and their biodegradability, as well as other properties (size distribution, ζ-potential) make the oligoesters considered as promising materials for the design of drug delivery systems.
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