1. JCCT
  2. Ch&ChT Vol. 19, No. 2, 2025
  3. Effect of Physico-Chemical Modification of Clinoptilolite Composites on Their Antimicrobial Activity

Effect of Physico-Chemical Modification of Clinoptilolite Composites on Their Antimicrobial Activity

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Volodymyr Vasylechko1,2, Volodymyr Sydorchuk3, Nazar Manko4, Oksana Kostiv1, Ol’ga Klyuchivska4, Oleksandra Ilkov5, Svitlana Bagday1, Anatoliy Zelinskiy1, Oleksandr Gromyko6, Rostyslav Stoika4, Yaroslav Kalychak1
Affiliation: 
1 Faculty of Chemistry, Ivan Franko National University of Lviv, 6 Kyryla & Mefodiya St., Lviv 79005, Ukraine 2 Department of Food Technology, Lviv University of Trade and Economics, 9 Samchuka St., Lviv 79011, Ukraine 3 Department of Heterogeneous Catalytic Oxidation Processes, Institute of Sorption and Problems of Endoecology, NAS of Ukraine, 13 General Naumov St., Kyiv 03164, Ukraine 4 Department of Regulation of Cell Proliferation and Apoptosis, Institute of Cell Biology, NAS of Ukraine, 14/16 Drahomanov St., Lviv 79005, Ukraine 5 Halychpharm, 6 Opryshkivska St., Lviv 79024, Ukraine 6 Faculty of Biology, Ivan Franko National University of Lviv, 4 Hrushevskoho St., Lviv 79005, Ukraine mankonazarcb@gmail.com
DOI: 
https://doi.org/10.23939/chcht19.02.183
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Keywords: 
clinoptilolite
microparticles
transition metals
physico-chemical and mechanochemical modifications
antimicrobial action
Abstract: 
Microparticles based on natural Transcarpathian clinoptilolite (CL), its H- and Na-forms are synthesized by physicochemical modifications, in particular, heat treatment and doping with metal activators (Ag and Cu). Doping of CL samples with metal ions was carried out in two different ways: the first was to use the solid-phase extraction method under dynamic conditions followed by mechanochemical treatment, and the second was to mechanochemically treat the CL samples with Ag and Cu compounds. XRD, SEM, EDX, FTIR-, UV-Vis-, XPS spectra, dispersity, porous structure parameters and antibacterial activity of the obtained compositions were studied. Modified forms are characterized by increased dispersion, larger specific surface area, porosity, increased number of hydroxyl OH groups and siloxane bonds. The inclusion of metals in the structure of CL contributed to the formation of active red-ox centers responsible for the formation of active oxygen-containing particles that participate in the destruction of microorganisms, which significantly increases the antibacterial activity of CL. The physical stability and biotolerance of CL in connection with the proposed approaches of physicochemical modification of zeolite will be useful for the preparation of new agents for the disinfection of contaminated surfaces in industry, agriculture, etc.
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