Development of High-Strength Bioactive Glass-Ceramic Materials for the Reconstruction of Long Bone Defects

Oksana Savvova1, Olena Babich1, Oleksii Fesenko1, Valentyna Maltseva2, Serhii Firsov1, Tetiana Shkolnikova3

Affiliation:

1 Department of Chemistry and Integrated Technologies, O.M. Beketov National University of Urban Economy in Kharkiv, 17 Chornoglazivska St., Kharkiv 61002, Ukraine 2 Laboratory of Connective Tissue Morphology, Sytenko Institute of Spine and Joint Pathology, National Academy of Medical Sciences of Ukraine, 80 Hryhoriia Skovorody St., Kharkiv 61024, Ukraine 3 Department of General and Inorganic Chemistry, National Technical University «Kharkiv Polytechnic Institute», 2 Kyrpychova St.,61002 Kharkiv, Ukraine Olena.Babich@kname.edu.ua

DOI:

https://doi.org/10.23939/chcht20.01.060

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Abstract:

The critical need for the restoration of the human musculoskeletal system, damaged due to osteoporosis, blast injuries, and congenital anomalies, has been identified. The needs of regenerative medicine aimed at the maximum possible restoration of the structure and functions of damaged tissues have been outlined. The necessity for the development of bioactive materials to substitute long bone defects through the creation of glass-ceramic materials with high biological activity and mechanical strength has been established. High-strength glass-ceramic materials have been developed through rapid low-temperature thermal treatment. These materials are characterized by the presence of bioactive phases such as hydroxyapatite and lithium phosphate, spodumene, eucryptite, diopside, and lithium disilicate. They can withstand significant mechanical (compressive strength 550–650 MPa, bending strength 350–450 MPa, fracture toughness 4.5–6.1 MPa•m0.5) and thermal (CTE = (40.5–79.2)•10-7°С-1) loads and are promising candidates for use as substitutes for bone tissue in long bone elements.

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Development of High-Strength Bioactive Glass-Ceramic Materials for the Reconstruction of Long Bone Defects

Keywords: