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Validation of a method to quantify platinum in cisplatin by inductively-coupled plasma

Maykel González Torres1, Carolina Muñoz Torres2, Ataulfo Martínez Torres3, Susana Vargas Muñoz4, Rogelio Rodríguez Talavera4, Álvaro de Jesús Ruíz-Baltazar4, Witold Brostow5,
Affiliation: 
1 Centro de Ciencias de la Complejidad, Universidad Nacional Autónoma de México, Circuito Exterior, Circuito Mario de la Cueva 20, Insurgentes Cuicuilco, Ciudad de México 04510, Mexico 2 Centro de Geociencias, Universidad Nacional Autónoma de México, Campus Juriquilla. Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro C.P 76230, Mexico 3 Laboratorio de Neurobiologia Molecular y Celular, Instituto de Neurobiología (INB), Universidad Nacional Autónoma de México, Querétaro 76230, Mexico 4 Centro de Física Aplicada y Tecnología Avanzada, Universidad Nacional Autónoma de México. Campus Juriquilla. Boulevard Juriquilla 3001, Santiago de Querétaro, Querétaro C.P 76230, Mexico 5 Department of Materials Science and Engineering, University of North Texas, 3940 North Elm Street, Denton, TX 76207, USA wkbrostow@gmail.com
DOI: 
https://doi.org/10.23939/chcht11.04.437
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Abstract: 
Cis-diaminedichloroplatinum(II), also known as cisplatin, has been quantified by use of inductively-coupled plasma. We measured cisplatin indirectly by determining the platinum concentration in the samples. We focus on the determination of Pt from cisplatin in water. We demonstrate that the total concentration of the drug can be quantified through the content of platinum with acceptable linearity, precision, repeatability, accuracy, limit of detection and limit of quantification. Our method is applicable among others for monitoring quality of control samples for cisplatin regulatory submissions and for determination of the cisplatin release profiles in biomarker implants in vitro.
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