Synthesis, Biological and Acidic Properties of Novel 2-Methoxy-6-[(3-Alkyl/Aryl-4,5-Dihydro-1H- 1,2,4-Triazol-5-one-4-yl)-Azomethin]-Phenyl p-Nitrobenzoate Derivatives
Affiliation:
1 Department of Chemistry, Kafkas University, Kars, 36100, Turkey
hhigh61@gmail.com
DOI:
https://doi.org/10.23939/chcht17.04.766
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Abstract:
3-Alkyl/Aryl-4-amino-4,5-dihydro-1H-1,2,4-triazol-5-ones (2) reacted with 2-(p-nitrobenzoxy)-3-methoxybenzaldehyde (3) to afford the corresponding 2-methoxy-6-[(3-alkyl/aryl-4,5-dihydro-1H-1,2,4-triazol-5-one-4-yl)-azomethin]-phenyl p-nitrobenzoates (4). The acetylation reactions of compounds 4 were investigated, and 5 type N-acetyl derivatives were obtained. The newly synthesized compounds were fully characterized. Also, in vitro antibacterial activities of the fourteen new compounds were screened against six bacteria according to agar well diffusion method. Finally, the newly synthesized 4 type compounds were titrated potentiometrically with tetrabutylammonium hydroxide (TBAH) in five non-aqueous solvents.
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