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Synthesis and Antiplatelet Activites of Some Derivatives of p-Coumaric Acid

Juni Ekowati1, Nuzul W. Diyah1, Achmad Syahrani1
Affiliation: 
1 Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Airlangga University, Jalan Dharmawangsa Dalam, Surabaya 60286, Indonesia juni-e@ff.unair.ac.id
DOI: 
https://doi.org/10.23939/chcht13.03.296
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Keywords:

Abstract: 
The synthesis of new derivatives of p-coumaric acid was carried out through serial reactions, i.e. alkylating, base hydrolysis, catalytic hydrogenation, and Fisher esterification. All reactions except catalytic hydrogenation were conducted by utilizing microwave irradiation from a household microwave oven. The antiplatelet tests using clotting time showed that p-coumaric acid and its derivatives have antiplatelet activity which is related to the lipophilic nature of the compounds and its affinity with the selected target molecule, i.e. COX-1 enzyme (PDB ID 1CQE).
References: 

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