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Synthesis of 6-R-3-(2-Aminophenyl)-2Н-1,2,4-Thriazin-5-ones: Resources and Limitations

Alexey Voskoboynik, Galina Berest, Dmitriy Skorina, Alexander Karpenko and Sergey Kovalenko
Affiliation: 
Lviv Polytechnic National University, 12, St. Bandery str.,79013 Lviv, Ukraine; vsergeev@.polynet.lviv.ua
DOI: 
https://doi.org/10.23939/chcht05.02.129
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Keywords:

Abstract: 
The novel methods of 6-R-3-(2-aminophenyl)-2Н-1,2,4-triazin-5-ones synthesis by 2-R-[(3H-quinazoline-4-yliden)hydrazono]--carboxylic acid esters hydrazinolysis and nucleophylic cleavage of 3-R-2H-[1,2,4]triazino[2,3-c]quinazoline-2-ones are worked out. It is shown that 2-R-[(3H-quinazoline-4-yliden)–hydrazono]--carboxylic acid esters under hydrazinolysis form (3Н-quinazoline-4-yliden)hydrazine or 6-R-3-(2-aminophenyl)-2Н-1,2,4-triazin-5-ones. The reaction direction depends on geometric isomerism of corresponding esters.
References: 

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