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Synthesis of 3S-Substituted Triazino[5,6-b]indoles and 4-Thiazolidinone-triazino[5,6-b]indole Hybrids with Antitumor Activity

Stefan Harkov, Dmytro Havrylyuk and Roman Lesyk
Affiliation: 
Danylo Halytsky Lviv National Medical University 69, Pekarska str, 79010 Lviv, Ukraine; dr_r_lesyk@org.lviv.net
DOI: 
https://doi.org/10.23939/chcht07.04.381
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Keywords:

Abstract: 
The synthesis and antitumor activity screening of 1,2,4-triazino[5,6-b]indoles based conjugates were performed. Reaction between 3-mercapto-1,2,4-triazino[5,6-b]indoles and several N-arylchloroacetamides yielded 3S-substituted 1,2,4-triazino[5,6-b]indoles. Based on 3-hydrazine-1,2,4-triazino[5,6-b]indoles the new 4-thiazolidinones have been synthesized. Seven synthesized compounds were tested for their anticancer activity in NCI60 cell lines.
References: 

[1] Pandeya S., Smitha S., Jyoti M. et al.: Acta Pharm., 2005, 55, 27.

[2] Kinsman O., Livermore D. and Smith C.: Antimicrobial Agents and Chemotherapy, 1993, 37, 1243.
https://doi.org/10.1128/AAC.37.6.1243

[3] Gladych J., Hornby R., Hunt J. et al.: J. Med. Chem., 1972, 15, 277.
https://doi.org/10.1021/jm00273a017

[4] DiCiollo C., Zarembo J. and Pagano J.: Xenobiotica, 1973, 3, 171.
https://doi.org/10.3109/00498257309151511

[5] Monge1 A., Palop J., Ramirez C. et al.: Eur. J. Med. Chem., 1991, 26, 179.

[6] Zhang Q., Ding D., Zeng S. et al.: Plos One, 2012, 7(10): e46294.
https://doi.org/10.1371/journal.pone.0046294

[7] Zhang Q., Zeng S. Zhang Yu et al.: EMBO Molecular Medicine, 2012, 4, 298.
https://doi.org/10.1002/emmm.201100211

[8] Lesyk R. and Zimenkovsky B.: Curr. Org. Chem., 2004, 8, 1547.
https://doi.org/10.2174/1385272043369773

[9] Havrylyuk D., Zimenkovsky B. and Lesyk R.: Phosphorus, Sulfur Silicon Relat. Elem., 2009, 184, 638.
https://doi.org/10.1080/10426500802247563

[10] Kaminskyy D., Khyluk D., Vasylenko O. and Lesyk R.: Tetrahedron Lett., 2012, 53, 557.
https://doi.org/10.1016/j.tetlet.2011.11.095

[11] Kaminskyy D., Khyluk D., Vasylenko O. et al.: Sci. Pharm., 2011, 79, 763.
https://doi.org/10.3797/scipharm.1109-14

[12] Lesyk R., Zimenkovsky B., Kaminskyy D. et al.: Biopolymers and Cell, 2011, 27, 107.
https://doi.org/10.7124/bc.000089

[13] Havrylyuk D., Mosula L., Zimenkovsky B. et al.: Eur. J. Med. Chem., 2010, 45, 5012.
https://doi.org/10.1016/j.ejmech.2010.08.008

[14] Mosula L., Zimenkovsky B., Havrylyuk D. et al.: Farmacia, 2009, 57, 321.

[15] Havrylyuk D., Zimenkovsky B., Vasylenko O. et al.: Eur. J. Med. Chem., 2009, 44, 1396.
https://doi.org/10.1016/j.ejmech.2008.09.032

[16] Panchuk R., Chumak V., Fil' M. et al.: Biopolymers and Cell, 2012, 28, 121.
https://doi.org/10.7124/bc.00003D

[17] Havrylyuk D., Zimenkovsky B., Vasylenko O. et al.: J. Med. Chem., 2012, 55, 8630.
https://doi.org/10.1021/jm300789g

[18] Havrylyuk D., Kovach N., Zimenkovsky B. et al.: Arch. Pharm. Chem. Life Sci., 2011, 344, 514.
https://doi.org/10.1002/ardp.201100055

[19] Popov-Pergal K., Cekovic Z. and Pergal M.: Zh. Obsh. Khim., 1991, 61, 1958.

[20] Monks A., Scudiero D., Skehan P. et al.: J. Nat. Cancer Inst., 1991, 83, 757.
https://doi.org/10.1093/jnci/83.11.757

[21] Boyd M. and Paull K:., Drug Dev. Res., 1995, 34, 91.
https://doi.org/10.1002/ddr.430340203

[22] Shoemaker R.: Nature Rev./Cancer, 2006, 6, 813.
https://doi.org/10.1038/nrc1951

[23] Rostom S.: Bioorg. Med. Chem., 2006; 14, 6475.
https://doi.org/10.1016/j.bmc.2006.06.020