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Synthesis of 2-Oxo(thio)-N,4-diaryl-1,2,3,4-tetrahydropyrimidine-5-carbothioamides

Olena Maiboroda and Nathaliia Simurova
Affiliation: 
National University of Food Technologies, 68, Volodymyrska St., 01601 Kyiv-33, Ukraine
DOI: 
https://doi.org/10.23939/chcht10.03.279
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Keywords:

Abstract: 
It was found that 2-acylthioacetamides enter Biginelli reaction with aromatic aldehydes and urea /thiourea forming 2-oxo(thio)-N,4-diaryl-1,2,3,4-tetrahydropyrimidine-5-carbothioamides. Under the influence of K3[Fe(CN)6] in alkaline environment, the expected 2-oxo(thio)-N,4-diaryl-5-(benzothiazole-2'-yl)-1,2,3,4-tetrahydropyrimidines were not been received while 2-oxo(thio)-N,4-diaryl-1,2,3,4-tetrahydropyrimidine-5-carbamides were the products of interaction.
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