Solubility of Ibuprofen in Conventional Solvents and Supercritical CO2: Evaluation of Ideal and Non-Ideal Models

Hamidreza Bagheri, Sattar Ghader, Negin Hatami
Department of Chemical Engineering, College of Engineering, Shahid Bahonar University of Kerman, Jomhoori Blvd., Kerman, Iran;
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In this study solubility of racemic (R/S)(±)-ibuprofen in pure conventional solvents (n-heptane, toluene, benzene and ethanol) and supercritical carbon dioxide is predicted and the results are compared with experimental data. The results of the ideal solubility show great deviation from experimental points. However, it seems that liquid phase non-ideality is the main problem in the modeling of this system. To capture the non-ideality of the system UNIQUAC, UNIFAC, NRTL, Wilson, and regular-solution theory are used. The results prove that UNIQUAC is more appropriate than regular-solution theory and UNIFAC for calculation of racemic (R/S)(±)-ibuprofen solubility data. Also, the solubility of (R/S)(±)-ibuprofen in supercritical CO2 (SC-CO2) was investigated by using Peng-Robinson equation of state (PR EoS). The results of modeling are in good agreement with experimental data.

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