Physico-Chemical Characterization of Bioactive Mixed Ligand Complexes of Antimony with 3,5-Diarylsubstituted Pyrazolinates and O,O’-Alkylene Dithiophosphates

Kanchan Lata Singh, Afshan Siddiqui, Kajal Singh, U.N. Tripathi
Affiliation: 
Department of Chemistry, DDU Gorakhpur University, Gorakhpur 273001, U.P., India kanchan100718@gmail.com
DOI: 
https://doi.org/10.23939/chcht13.04.407
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Abstract: 
Antimony(III) complexes of 3(2’-hydroxyphenyl)-5-(4’-substituted phenyl) pyrazolinates and O,O’-alkylene dithiophosphate of the type [Sb(C15H12N2OX)(GO2PS2)]Cl and [Sb(C15H12N2OX)2(GO2PS2)] (where GO2PS2 – deprotonated O,O’-alkylene dithiophosphate; C15H12N2OX – deprotonated 3(2'-hydroxyphenyl)-5-(4’-subsitutedphenyl) pyrazolinates; X = –H,–CH3, –OCH3 and –Cl; G = –C(CH3)2CH2CH(CH3)–) have been synthesized and characterized by elemental analysis (C, H, N, Cl and Sb), molecular weight study by FAB mass, electronic spectral studies, far and mid IR, multinuclear NMR (1H,13C and 31P). On the basis of above spectral studies, coordination of dithiophosphate and pyrazolinates along with the compounds structure have been discussed tentatively. All complexes were tested for in vitro antibacterial and antifungal activity, exhibiting a very good antibacterial and antifungal activity. Few complexes were also tested for their antiviral activity against papya ringspot virus showing a significant antiviral activity with inhibition of approximately 34.30 %.
References: 

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