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Microwave-Assisted Synthesis of Bis-(Hydroxybenzylidene)-Cycloalkanones via Acid Catalyzed Claisen-Schmidt Condensation

Eunike Adabella1, Cindy A. W. Oei1, Vania A. Rantetasak1, Tutuk Budiati1, Ami Soewandi1
Affiliation: 
1 Faculty of Pharmacy, Widya Mandala Catholic University Surabaya, Jl. Kalisari Selatan No.1 Kalisari, Pakuwon City, Kec. Mulyorejo, Surabaya, Jawa Timur 60112, Indonesia tutuk@ukwms.ac.id
DOI: 
https://doi.org/10.23939/chcht18.03.350
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Keywords:

Abstract: 
In the present study, bis-(hydroxybenzylidene)cycloalkanone derivatives were synthesized by Claisen-Schmidt condensation using cycloalkanones and arylaldehydes in the presence of HCl as an acid catalyst. The synthetic reaction was carried out under microwave irradiation. The structure of the synthesized compounds was determined by UV, IR, 1H NMR spectroscopic methods. The obtained reaction yields were not optimal due to the self-polymerization of p-hydroxybenzaldehyde in an acid solution.
References: 

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