Kinetic Spectrophotometric Method for the Determination of Suxamethonium Chloride

Mykola Blazheyevskiy and Lyubomyr Kryskiw
Affiliation: 
National University of Pharmacy, 61002 Kharkiv, Ukraine; blazejowski@ ukr.net; soul_fly@meta.ua
DOI: 
https://doi.org/10.23939/chcht09.03.261
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Abstract: 
A novel selective, simple, sensitive, and cost effective kinetic spectrophotometric initial rate method for the determination of suxamethonium chloride has been developed. It is based on the indicator reaction of catalytic 3,3',5,5'-tetramethylbenzidine oxidation. The analytical performance of the method was validated statistically with respect to limit of detection (LOD) and limit of quantitation (LOQ), accuracy, precision, and linearity.
References: 

[1] Sweetman S.: Martindale: The Complete Drug Reference. Pharmaceutical Press, London 2007.

[2] British Pharmacopoeia, The Stationery Office on behalf of the Medicines and Healthcare products Regulatory Agency, London 2009.

[3] United States Pharmacopoeia 30 and NF 25, American Pharmaceutical Association, Washington, DC 2007.

[4] Tsutsumi H., Nishikawa M., Katagi M, et al.: J. Health Sci., 2003, 49, 285.
https://doi.org/10.1248/jhs.49.285

[5] Aubeck R., Brauchle C. and Hampp N.: Anal. Chim. Acta 1990, 238, 405.
https://doi.org/10.1016/S0003-2670(00)80566-8

[6] Luterotti S. and Maysinger D.: J. Pharm. Biomed. Anal., 1994, 12, 1083.
https://doi.org/10.1016/0731-7085(94)00050-6

[7] Patterson B., Danielson N. and Sommer A.: Anal. Chem., 2004, 76, 3826.
https://doi.org/10.1021/ac0400111

[8] Roy J., Boismenu D., Gao H. et al.: Anal. Biochem., 2001, 290, 238.
https://doi.org/10.1006/abio.2000.4956

[9] Chen S., Soneji V. and Webster J.: J. Chromatogr. A, 1996, 739, 351.
https://doi.org/10.1016/0021-9673(96)00215-4

[10] Gao H., Roy S., Donati F. et al.: J. Chromatogr. B, 1998, 718, 129.
https://doi.org/10.1016/S0378-4347(98)00350-8

[11] Lagerwerf A., Vanlinthout L. and Vree T.: J. Chromatogr. B, 1991, 570, 390.
https://doi.org/10.1016/0378-4347(91)80543-L

[12] Rahman N., Anwar N. and Kashif M.: Chem. Pharm. Bull., 2006, 54, 33.
https://doi.org/10.1248/cpb.54.33

[13] Nussbaumer S., Fleury-Souverain S., Rudaz S. et al.: J. Pharm. Biomed. Anal., 2009, 49, 333.
https://doi.org/10.1016/j.jpba.2008.11.018

[14] Blazheyevskiy M.: III Conf. "Dynamika Naukovykh Doslidzhen". Ukraine, Dnipropetrovsk 2004, 5.

[15] Blazheyevskiy M.: Voprosy Khimii i Khim. Techn., 2003, 3, 19.

[16] Derzhavna Farmakopeya Ukrayiny, RIREH, Kharkiv 2001.

[17] Josephy P., Eling T. and Mason R.: J. Biol. Chem., 1982, 257, 3669.

[18] Blazheyevskiy M. and Kryskiw L.: Farmatsevtychnyy Zh., 2012, 6, 67.

[19] Hryzodub A., Leont'ev D., Denysenko N. et al.: Farmakom, 2004, 3, 1.