Influence of Ni (II), Cu (II) and Zn (II) complex formation on interaction with model cellular membranes

Liya Khmars’ka1, Kostyantyn Kylyvnyk2 and Olexandr Shtemenko1
1Ukrainian State University of Chemical Technology, 8 Gagarin Ave, Dnipropetrovsk, Ukraine, 49005 2 NanoEner Inc., Fort Lauderdale, FL, USA, 33309
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Influence of complex compounds of nickel (II), copper (II) and zinc (II) with nitrogen containing ligands on conductivity of bilayer lipid membranes (BLMs) was studied. The role of conditions (pH, metal and ligand concentration) on complex formation and interaction with BLMs was evaluated. Composition and form of complex ions in solution which maximally change conductivity have been calculated. Relationship between the complex form predominant in the solution and BLM conductivity indicated that complex ions influence mostly depended on surrounding ligands and did not depend on the nature of the central atom. Permeability coefficients for complex ions which maximally changed BLM conductivity were calculated.

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