A Green and Efficient Solvent- and Catalyst-Free Ultrasonic Dibenzylation Procedure

Somayyeh Heydari1, Davood Habibi2, Alireza Faraji3
1 SavehUniversityofMedicalSciences, SavehIran 2 DepartmentofOrganicChemistry, FacultyofChemistry, Bu-AliSinaUniversity, Hamedan, Iran 3 ActivePharmaceuticalIngredientsResearchCenter, PharmaceuticalSciencesBranch, IslamicAzadUniversity (IAUPS), Tehran, Iran somi.heydari@gmail.com; davood.habibi@gmail.com
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A greener improvement was achieved for the synthesis of diverse N,N-dibenzylated compounds from the reaction of various aromatic amines with benzyl bromide using the ultrasound irradiation in solvent- and catalyst-free conditions. The dibenzylation reactions were carried out in different solvents and solvent-free conditions under ultrasound irradiation at various temperatures. The yields were very low in all applied solvents, while in the solvent-free condition and at room temperature, the yields were excellent. Due to obtaining the high reaction yields, the catalyst was not used.

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