Arylsubstituted Halogen(thiocyanato)amides Containing 4-Acetylphenyl Fragment. Synthesis, Cyclization and Antimicrobial Properties

Vitaliy Baranovskyi1, Ruslan Symchak1, Olena Pokryshko2, Sergiy Klymnyuk2, Bogdan Grishchuk1
1 Ternopil V. Hnatyuk National Pedagogical University 2, Kryvonosa St., 46027 Ternopil, Ukraine 2 I. Ya. Horbachevsky Ternopil State Medical University 1, Volya Sq., 46001 Ternopil, Ukraine
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3-(4-Acetylphenyl)-(2-methyl)-2-chloro(bromo, thiocyanato)propanamides have been obtained via copper catalytic anionarylation of acrylic and methacrylic acids amides by 4-acetylphenyldiazonium salts. 5-(4-Acetylphenyl)substituted 2-aminothiazol-4(5H)-ones were synthesized by cyclisation of thiocyanatoamides. All synthesized compounds were tested for their antibacterial and antomycotic activity.

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