1. JCCT
  2. Ch&ChT Vol. 19, No. 3, 2025
  3. Synthesis, Identification, and Evaluation of Antibacterial Activity of Some New 4,5-Dihydro-1H-Pyrazoles, Derivatives from Substituted Chalcones

Synthesis, Identification, and Evaluation of Antibacterial Activity of Some New 4,5-Dihydro-1H-Pyrazoles, Derivatives from Substituted Chalcones

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Jawdat Abdulwahid1, Saad Jasim2, Shakhawan Beebany2
Affiliation: 
1 Environmental and Pollution Engineering Department, Technical Engineering College, Kirkuk, Northern Technical University, Mosul, Iraq 2 Department of Chemistry, College of Sciences, University of Kirkuk, Kirkuk, Iraq sh.beebany@uokirkuk.edu.iq
DOI: 
https://doi.org/10.23939/chcht19.03.482
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Keywords: 
chalcones
hydrazine
cyclization
pyrazole
antibacterial effect
Abstract: 
In this work, a series of new 4,5-dihydro-1H-pyrazole derivatives (M21-M25) has been synthesized successfully via the reaction of different aldehydes with ketones to produce chalcones, followed by the reaction with hydrazine and phenyl hydrazine. The prepared compounds were identified using FT-IR spectroscopy, 1H NMR spectroscopy, and 13C NMR spectroscopy. The biological activity of these prepared compounds was preliminarily evaluated against certain types of gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli). The results showed a high antibacterial effect towards both types of bacteria at high concentrations.
References: 

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