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Development of New Antimicrobial Compositions of Thiosulfonate Structure

Vira Lubenets1, Olena Karpenko2, Mykola Ponomarenko3, Gleb Zahoriy4, Aelita Krychkovska1 and Volodymyr Novikov1
Affiliation: 
1 Lviv Polytechnic National University; 12, S. Bandery str., 79013 Lviv, Ukraine 2 Department of Physico-Chemistry of Combustive Minerals, L.M. Lytvynenko InPOCC, NAS of Ukraine, 3a, Naukova str., 79053 Lviv, Ukraine 3 Kyiv Medical Academy of Postgraduate Education; 9, Dorohozhytska str., 04112 Kyiv, Ukraine 4 JSC "Darnytsia", Kyiv, Ukraine
DOI: 
https://doi.org/10.23939/chcht07.02.119
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Abstract: 
The antimicrobial composition based on the substance of thiosulfonate structure (ETS) and surfactants of microbial origin (biosurfactants) in the form of stable suspensions and ointments were developed and investigated for their effectiveness. The application of biosurfactants in the preparation enhances the antifungal and antibacterial activity of ETS and reduces its active concentration. The economic calculations have shown that the developed antimicrobial composition has a low cost and is competitive compared with antifungal agents present in the pharmaceutical market.
References: 

[1] Takada N., Watanabe N., Suenaga K. et al.: Tetrahedron Lett., 2001, 42, 6557.
https://doi.org/10.1016/S0040-4039(01)01314-4

[2] Block E., Thiruvazhi M., Toscano P. et al.: J. Am. Chem. Soc., 1996, 118, 2790.
https://doi.org/10.1021/ja951134t

[3] Block E. and Shu-Hai Z.: J. Org. Chem., 1992, 57, 5815.
https://doi.org/10.1021/jo00048a007

[4] Boldyrev B. and Zakharchuk A.: Dokl. Acad. Nauk SSSR, 1954, XCIV, 877.

[5] Boldyrev B., Bilozor T., Vlyazlo R. et al.: [in:] Anisimov A. (Ed.), Biopovregdeniya v Promyshlennosti, Sbornik Trudov. Gork. Gos.Univ., Gorkiy 1983, 44.

[6] Aizenman B., Skorobagatko T., Boldyrev B. and Aristarkhova L.: Physiol. Act. Veshestva, 1975, 7, 113.

[7] Sebille B., Beuzard Y. and Demarne H. : Pat. 2573077 France, Publ. May 16, 1986.

[8] Hayashi S., Furukawa M., Jamamoto J. and Hamamura K.: Chem. Pharm. Bull., 1967, 15, 1310.
https://doi.org/10.1248/cpb.15.1310

[9] MacDonald J., Marchand M. and Langler R.: Blood Coagulation & Fibrinolysis, 2004, 15, 447.
https://doi.org/10.1097/00001721-200408000-00002

[10] Khomchenovskyi E., Boldyrev B. and Bilozor T.: Dokl. Acad. Nauk SSSR, 1960, 170, 1453.

[11] Frankenberg L.: Arch. Toxicol., 1980, 45, 315.
https://doi.org/10.1007/BF00293812

[12] Karpenko O., Martynyuk N., Shulga O. et al.: Pat. Ukr. 71792 A 15, Publ. Dec.12, 2004.

[13] Kolwzan B., Biazik J., Czarny A. et al.: Ekotoksykologia w Ochronie Srodowiska, 2008, 884, 191.

[14] Karpenko E., Pokinbroda T., Makitra R. and Pal'chikova E.: Zh. Obsh. Khim., 2009, 79, 2637.

[15] Banat I., Franzetti A., Gandolfi I. et al.: Appl. Microbiol. Biotechn., 2010, 87, 427.
https://doi.org/10.1007/s00253-010-2589-0

[16] Pacwa-Plociniczak M., Plaza G., Piotrowska-Seget Z. and Cameotra S.: Int. J. Mol. Sci., 2011, 12, 633.
https://doi.org/10.3390/ijms12010633

[17] Lubenets V., Vasilyuk S., Baranovych D. and Novikov V.: Pat. Ukr. 200510507, Publ. July 15, 2006.

[18] Sotirova A., Avramova T., Stoitsova S. et al.: Curr. Microbiol, 2012, 65, 534.
https://doi.org/10.1007/s00284-012-0191-7

[19] Sotirova A., Avramova T., Lazarkevich I. et al.: Comptes Rendus de L'Academie Bulgare des Sciences, 2010, 6, 21.