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Salicylic Acid as a Bio-Based, Natural and Versatile Catalyst for Green, Solvent-Free and One-Pot Biginelli Synthesis of 3,4-Dihydropyrimidin-2-(1H)-one/thione Derivatives

Farzaneh Mohamadpour
Affiliation: 
Young Researchers and Elite Club, Shiraz Branch, Islamic Azad University, Shiraz, Iran Mohamadpour.f.7@gmail.com
DOI: 
https://doi.org/10.23939/chcht13.02.136
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Keywords:

Abstract: 
A green synthetic route for eco-safe and solvent-free preparation of biologically active 3,4-dihydropyrimidin-2-(1H)-ones/thiones derivatives via one-pot, three-component Biginelli condensation reaction of β-keto esters (methyl or ethyl acetoacetate), aromatic aldehyde (benzaldehyde derivatives) and urea or thiourea have been developed using a salicylic acid as a bio-based, natural and versatile catalyst. The notable advantages of this green approach are use of the bio-based, natural, easy-to-handle and readily green catalyst, easy work-up process, absence of hazardous organic solvents, solvent-free conditions with high to excellent yields and short reaction times and one-pot reactions. The products have been characterized by melting points and 1H NMR spectroscopy.
References: 

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