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One-Pot Synthesis, Antioxidant Activity and Toxicity Evaluation of Some Hydroxyxanthones

Emmy Yuanita1, 2, Harno Dwi Pranowo2, Dwi Siswanta2, Respati Tri Swasono2, Mustofa3, Abdul Karim Zulkarnain4, Jufrizal Syahri5, Jumina2,
Affiliation: 
1 Faculty of Mathematics and Natural Science, Universitas Mataram, 83236 Mataram, Indonesia 2 Faculty of Mathematics and Natural Science, Universitas Gadjah Mada, 55281 Yogyakarta, Indonesia 3 Faculty of Medicine,Universitas Gadjah Mada, 55281 Yogyakarta, Indonesia 4 Faculty of Pharmacy, Universitas Gadjah Mada, 55281 Yogyakarta, Indonesia 5 Faculty of Mathematics and Natural Science, Universitas Muhammadiyah Riau, 28291 Pekanbaru, Indonesia emmy.yuanita@unram.ac.id jumina@ugm.ac.id
DOI: 
https://doi.org/10.23939/chcht12.03.290
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Keywords:

Abstract: 
Some new hydroxyxanthone compounds were prepared through one pot cyclodehydration reaction of hydroxybenzoic acid derivatives (salicylic acid or resorcylic acid) with phloroglucinol or pyrogallol in the presence of Eaton’s reagent (P2O5/MeSO3H). The synthesized compounds were screened for their antioxidant activities by 2,2-diphenyl-1-picrylhydrazyl (DPPH) methods to determine their inhibitory concentration (IC50). Cytotoxicity of the prepared compounds was also evaluated by MMT assay on Vero cell line. It was observed that the position and the number of hydroxyl groups could significantly affect the potent antioxidant activity of the prepared compounds. Cytotoxicity evaluation of new compounds indicated that the synthesized series of hydroxyl xanthone were categorized as very strong antioxidants and showed potential development as a commercial antioxidant compound.
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