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Synthesis and Evaluation of Hypoglycemic Activity of New Pyrazolothiazolidine Hybrid Structures

Nadiya Panasenko1, Mykhailo Bratenko1, Viktor Zvarych2, Maryna Stasevych2, Mykhailo Vovk3
Affiliation: 
1 Bucovinian State Medical University, 2, Teatralna Sq., 58002 Chernivtsi, Ukraine 2 Lviv Polytechnic National University, 12, S. Bandera Str., 79013 Lviv, Ukraine 3 Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 5, Murmanska Str., 02660 Kyiv, Ukraine panasenko.n@bsmu.edu.ua
DOI: 
https://doi.org/10.23939/chcht14.03.284
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Keywords:

Abstract: 
New promising pyrazolothiazolidine hybrid structures, containing a methylenehydrazone linker between functionalized pyrazole and thiazolidine cycles, have been obtained using cyclocondensation of 3-aryl-4-formylpyrazole thiosemicarbazones and diethyl acetylenedicarboxylate in mild reactional conditions. The acetic acid was proposed as a catalytic agent for the synthesis of ambident bi-center thiosemicarbazones as reagents for further formation of the thiazolidine cycle. The obtained pyrazolothiazolidines were found to exhibit hypoglycemic activity by in vivo study of glucose level in the blood of rats after oral administration of synthesized derivatives
References: 

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