The Synthesis and Antimicrobial Properties of New 2-(R-Phenylimino)-1,3-thiazoline Derivatives Containing the N-Methylpiperazine Moiety

Hanna Yeromina1, Nataliya Demchenko2, Olga Kiz1, Zinaida Ieromina1, Sergiy Demchenko3
Affiliation: 
1 National University of Pharmacy, 53, Pushkinska St., 61002 Kharkiv, Ukraine 2 Chernihiv National T.G. Shevchenko Pedagogical University, 53, Hetmana Polubotka St., 14013 Chernihiv, Ukraine 3 Institute of Pharmacology and Toxicology, National Academy of Medical Sciences, 14, Eugene Potter St., 03057 Kyiv, Ukraine annerem2012@gmail.com
DOI: 
https://doi.org/10.23939/chcht13.02.150
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Abstract: 
New derivatives of N-(R-phenyl)-3-(4-methyl-1-piperazinyl)-1,3-thiazole-2(3H)- imine with the medium to high yields were synthesized by the Hantzsch reaction in the ethanol medium. The structure of target compounds was confirmed by elemental analysis and NMR spectroscopy. The antimicrobial activity of 1,3-thiazoline derivatives with the N-methylpiperazine moiety against sulfate-reducing bacteria of Desulfovibrio sp. М.4.1 strain was studied. It was found that substances containing the halo- and unsubstituted phenyl fragment in the position 4 of the thiazoline cycle showed the potent antimicrobial activity.
References: 

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