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Study of Biodegradation, Biocompatibility and Bactericidal Activity of Film Materials with Tiamulin Fumarate Based on Polyurethaneurea

Tetiana Vislohuzova1, Rita Rozhnova1, Natalia Galatenko1, Larysa Narazhayko1, Ada Rudenko2
Affiliation: 
1 Institute of Macromolecular Chemistry of the NAS of Ukraine, 48, Kharkivske Hwy., 02160 Kyiv, Ukraine 2 Institute of Urology of the National Academy of Medical Sciences of Ukraine, 9а, V. Vynnychenka St., 04053 Kyiv, Ukraine rudenchyk@gmail.com
DOI: 
https://doi.org/10.23939/chcht14.03.318
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Keywords:

Abstract: 
The influence of the model biological medium 199 on the structure and properties of film materials with tiamulin fumarate based on polyurethaneurea containing in its structure the hydrophilic fragments of the copolymer of N-vinylpyrrolidone with vinyl acetate and vinyl alcohol has been investigated. According to IR spectroscopy, under the influence of the biological medium 199 there are processes of biodegradation of polymer materials which are accompanied by a decrease in the intensity of the absorption band νС=О of vinylpyrrolidone ring. It is established that the introduction of tiamulin fumarate into polyurethaneurea facilitates their biodegradation, as evidenced by a decrease of the tensile strength (1.28–2.38 times) and a relative elongation at break (1.36–1.82 times) after incubation in the biological medium 199 by physico-mechanical tests. The tissue culture method has established the biocompatibility of film materials with tiamulin fumarate. According to the results of microbiological studies, bactericidal properties were observed in relation to the bacteria Staphylococcus aureus and Escherichia coli. It allows using them for production of drainage in abdominal surgery.
References: 

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