Structural and Colloidal-Chemical Characteristics of Nanosized Drug Delivery Systems Based on Pegylated Comb-Like Carriers

Anna Riabtseva1, Nataliya Mitina1, Nataliya Boiko2, Sergiy Garasevich3, Igor Yanchuk4, Rostyslav Stoika2, Oleksandr Slobodyanyuk3, and Alexander Zaichenko1
1 Lviv Polytechnic National University, 12 S. Bandera str., 79013 Lviv, Ukraine; 2 Institute of Cell Biology, National Academy of Sciences of Ukraine, 14/16 Drahomanova str., 79005 Lviv, Ukraine 3 Taras Shevchenko National University, 64 Volodymyrs'ka str., 01601 Kyiv, Ukraine 4 NanoMedTech LLC, 68 Gor’kogo str., 03150 Kyiv, Ukraine
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Novel comb-like polymeric and oligomeric drug carriers combining backbone – copolymers of 5-tert-butylperoxy-5-methyl-1-hexene-3-yne (VEP) and glycidyl methacrylate (GMA) – and side PEG chains of various lengths were synthesized. Nanosized delivery systems containing conjugates of water soluble anticancer drug Doxorubicin were developed. The structures of copolymers and their conjugates with drugs were confirmed by IR-spectroscopy. Structural and colloidal-chemical properties of water drug delivery systems were studied using photoluminescent (PL), UV-spectroscopy techniques, surface tension measurements and dynamic light scattering. The scheme of the immobilization of water soluble doxorubicin on developed PEGylated polymeric carriers was assumed.

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