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Possibility of Using Embolizing Preparation Derived from Poly(2-Hydroxyethyl Methacrylate) (Poly-HEMA) for Chemoemobolization

Elena Koverzanova1, Sergei Usachev1, Klara Gumargalieva1 and Leonid Kokov2
Affiliation: 
1 N.N. Semenov Institute of Chemical Physics, RAS, 4 Kosygin st., Moscow 11999, Russia, stusl@chph.ras.ru 2 A.V. Vishnevsky Institute of Surgery, 27 Bol. Serpukhovskaya st., Moscow 115093, Russia.
DOI: 
https://doi.org/10.23939/chcht03.01.073
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Keywords:

Abstract: 
The principal opportunity of uptaking weakly crosslinked hydrogel emboli is shown by Doxorubicin at different temperatures. The optimal process time is 1.5–2.5 h. It is revealed that Doxorubicin is capable to diffuse from a polymeric matrix, having targeted medical effect on surrounding tissue and reducing side impacts on other organs.
References: 

[1] Pavlovsky A.: Prakticheskaya Onkologiyas, 2004, 5, 108.

[2] Jelinkova M., Strohalm J., Etrych T. et al.: Pharmaceutical Research, 2003, 20, 1557.
https://doi.org/10.1023/A:1026170830782

[3] Horak D., Gumargalieva K., Zaikov G.: [in:] Zaikov G. (Ed.) Chemical reactions in liquid and solid phase. Nova Science Publ., New York 2003, 11-59.

[4] Horak D., Guseinov E., Vishnevskii V. et al.: J. Biomed. Mater. Res., 2000, 5, 184.
https://doi.org/10.1002/(SICI)1097-4636(200008)51:2<184::AID-JBM6>3.0.CO;2-O

[5] Adamyan A., Kokov L., Titova M. et al.: Russian Federation Patent No. 61120, 2007.

[6] Adamyan A., Gumargalieva K., Dan V. et al.: Patent of USSR No. 1403418, 1988.