The New 1,2,3-Triazolylantracene-9,10-Diones: Synthesis and ComputerBioactivity Screening

Maryna Stasevych1, Viktor Zvarych1, Volodymyr Lunin1, Mykhailo Vovk2 and Volodymyr Novikov1
1 Lviv Polytechnic National University, 12, Bandera St., 79013 Lviv, Ukraine; 2 Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 5, Murmanska St., 02660 Kyiv,Ukraine;
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The reactions of 1,4(1,5)-diazido-9,10-anthracenediones with phenylacetylene and methyl propiolate under copper(I)-catalyzed reaction of the azide-alkyne cycloaddition conditions have been studied and a series of new 1,2,3-triazole derivatives of 9,10-anthracendione have been obtained. The computer screening of synthesized compounds was carried out using the PASS Online software to identify areas of experimental biomedical researches. Compounds with high affinity to the receptors family of tyrosine kinases of the epidermal growth factor EGFR have been found among the newly synthesized 1,2,3-triazoles of 9,10-anthracenedione using molecular docking. The results of molecular docking indicate a probable mechanism for the realization of antitumor activity.

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