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Dependence of Phenol Toxicity on Kind and Position of Substitutes

Irina Belostotskaja, Elena Burlakova, Vyacheslav Misin, Grigory Nikiforov, Natalia Khrapova and Valentina Shtol’ko
Affiliation: 
N.M. Emanuel Institute of Biochemical Physics of Russian Academy of Sciences, 4, Kosygin str., 119334 Moscow, Russia
DOI: 
https://doi.org/10.23939/chcht07.04.457
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Keywords:

Abstract: 
Toxicity of 28 phenol derivatives with different alkyl substitutes in 2-, 6-positions and NH2 , CN, ОН functional groups in 4-position was studied. The least toxicity has phenols with two tert-butyl substitutes in o-position. The toxicity increases with functional p-substitutes removal from benzene nuclei. The obtained results can help to synthesize new nontoxic bioactive phenols.
References: 

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