Error message

  • Deprecated function: Unparenthesized `a ? b : c ? d : e` is deprecated. Use either `(a ? b : c) ? d : e` or `a ? b : (c ? d : e)` in include_once() (line 1439 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Array and string offset access syntax with curly braces is deprecated in include_once() (line 3557 of /home/science2016/public_html/includes/bootstrap.inc).

Application of Infrared Spectroscopy and X-Ray Powder Diffractometry for Assessment of the Qualitative Composition of Components in a Pharmaceutical Formulation

Maryna Stasevych1, Viktor Zvarych1, Mykhailo Dronik1, Martyn Sozanskyi1, Semen Khomyak1
Affiliation: 
1 Lviv Polytechnic National University, 12 S. Bandera St., 79013 Lviv, Ukraine maryna.v.stasevych@lpnu.ua
DOI: 
https://doi.org/10.23939/chcht17.03.510
AttachmentSize
PDF icon full_text.pdf967.75 KB

Keywords:

Abstract: 
A qualitative assessment of a new four-component pharmaceutical composition has been carried out using the methods of infrared spectroscopy and X-ray powder diffractometry. Qualitative characteristics for the identification of mixture components by absorption bands in infrared spectra and characteristic peaks by positions on the scattering angle 2θ scale in diffractograms were determined. It was experimentally confirmed that the quantitative content of benzocaine and procaine hydrochloride in the mixture without diclofenac sodium decreased by two times compared to their content in the mixture with it. Original infrared spectra and X-ray diffractograms of the new pharmaceutical composition with diclofenac sodium, which can be used for its identification, are presented.
References: 

[1] Elzayat, E.M.; Abdel-Rahman, A.A.; Ahmed S.M.; Alanazi, F.K.; Habib, W.A.; Sakr, A. Studying the Impact of Formulation and Processing Parameters on the Release Characteristics From Hydroxypropyl Methylcellulose Matrix Tablets of Diclofenac. Acta Pol. Pharm. 2016, 73, 439-452.

[2] Stasevych, M.; Zvarych, V.; Musyanovych, R.; Novikov, V.; Vovk, M. Synthesis of N-benzoyl-N'-(9,10-dioxo-9,10-dihydroanthacen-1-yl)-thioureas and Quantum-Chemical Analysis of the Reaction Passing. Chem. Chem. Technol. 2014, 8, 135-140. https://doi.org/10.23939/chcht08.02.135
https://doi.org/10.23939/chcht08.02.135

[3] Zvarych, V.I.; Stasevych, M.V.; Lunin, V.V.; Vovk, M.V.; Novikov, V.P. Synthesis of (1H-pyrrol-1-yl)anthracene-9,10-diones. Chem. Heterocycl. Compd. 2016, 52, 421-423, https://doi.org/10.1007/s10593-016-1904-9
https://doi.org/10.1007/s10593-016-1904-9

[4] Stasevych, M.V.; Plotnikov, M.Y.; Platonov, M.O.; Sabat, S.I.; Musyanovych, R.Y.; Novikov, V.P. Sulfur-containing Deriva-tives of 1,4-Naphthoquinone, Part 1: Disulfide Synthesis. Heteroa-tom Chem. 2005, 16, 205-211. https://doi.org/10.1002/hc.20112
https://doi.org/10.1002/hc.20112

[5] Ibis, C.; Ozsoy-Gunes, Z.; Tuyun, A.F.; Ayla, S.S.; Bahar, H.; Stasevych, M.; Mysyanovych, R.; Komarovska-Porohnyavets, O.; Novikov, V. Synthesis, Antibacterial And Antifungal Evaluation of Thio- or Piperazinyl-Substituted 1,4-Naphthoquinone Derivatives. J. Sulfur Chem. 2016, 37, 477-487. https://doi.org/10.1080/17415993.2016.1187734
https://doi.org/10.1080/17415993.2016.1187734

[6] Zvarych, V.I.; Stasevych, M.V.; Stanko, O.V.; Komarovska-Porokhnyavets, O.; Poroikov, V.V; Rudik, A.V.; Lagunin, A.A.; Vovk, M.V.; Novikov, V. Computerized Prediction, Synthesis, and Antimicrobial Activity of New Amino-Acid Derivatives of 2-Chloro-N-(9,10-Dioxo-9,10-Dihydroanthracen-1-yl)Acetamide. Pharm. Chem. J. 2014, 48, 582-586. https://doi.org/10.1007/s11094-014-1154-z
https://doi.org/10.1007/s11094-014-1154-z

[7] Stasevych, M.; Zvarych, V.; Khomyak, S; Lunin, V.; Kopak, N.; Novikov, V.; Vovk, M. Proton-initiated Conversion of Dithiocarbamates of 9,10-Anthracenedione. Chem. Chem. Technol. 2018, 12, 300-304. https://doi.org/10.23939/chcht12.03.300
https://doi.org/10.23939/chcht12.03.300

[8] Stasevych, M.; Zvarych, V.; Lunin, V.; Vovk, M.; Novikov, V. The New 1,2,3-Triazolylantracene-9,10-diones: Synthesis and Computer Bioactivity Screening. Chem. Chem. Technol. 2017, 11, 1-9. https://doi.org/10.23939/chcht11.01.001
https://doi.org/10.23939/chcht11.01.001

[9] Analytical Methods Committee. Fourier Transform Infrared Spectroscopic Analysis of Organic Archaeological Materials: Back-ground Paper. Anal. Methods 2021, 3, 2997-3000. https://doi.org/10.1039/D1AY90064A
https://doi.org/10.1039/D1AY90064A

[10] Derzhavna Farmakopeya Ukrayiny : v. 1. In Derzhavne pid-pryyemstvo «Ukrayins'kyy naukovyy farmakopeynyy tsentr yakosti likars'kykh zasobiv»; 2-e vyd.; Kharkiv: Derzhavne pidpryyemstvo «Ukrayin s'kyy naukovyy farmakopeynyy tsentr yakosti likars'kykh zasobiv», 2015.

[11] Sozanskyi, M.; Stadnik, V.; Shapoval, P.; Yatchyshyn, Io.; Guminilovych, R.; Shapoval, S. Optimization of Synthesis Condi-tions of Mercury Selenide Thin Films. Chem. Chem. Technol. 2020, 14, 290-296. https://doi.org/10.23939/chcht14.03.290
https://doi.org/10.23939/chcht14.03.290

[12] Sozanskyi, M.; Stadnik, V.; Chaykivska, R.; Guminilovych, R; Shapoval, P.; Yatchyshyn, Io. Synthesis and Properties of Mer-cury Selenide Films Deposited by Using Pottasium Iodide as Com-plexing Agent. Chem. Chem. Technol. 2017, 11, 445-448. https://doi.org/10.23939/chcht11.04.445
https://doi.org/10.23939/chcht11.04.445

[13] Litteer, B.; Beckers, D. Increasing Application of X-Ray Powder Diffraction in the Pharmaceutical Industry. American Laboratory (Fairfield) А [Online] 2005, 37, 22-24. https://www.americanlaboratory.com/914-Application-Notes/36153-Increasin... (accessed Dec 6, 2022).

[14] Manjunath, A.; Ashwini, A.; Mahalesh, D.; Balaji, B.; Mohanraj, P.; Kerur, B.R. Qualitative Analysis of Pharmaceutical Drugs by X-Ray Transmission Method: A non-Destructive Technique. Proceedings of the AIP Conference, India (Indore), December 27-28, 2018, 2100, 020114. https://doi.org/10.1063/1.5098668
https://doi.org/10.1063/1.5098668

[15] Orimolade, B.O.; Arotiba, O.A. Enhanced Photoelectro-catalytic Degradation of Diclofenac Sodium Using a System of Ag-BiVO4/BiOI Anode and Ag-BiOI Cathode. Sci. Rep. 2022, 12, 4214. https://doi.org/10.1038/s41598-022-08213-0
https://doi.org/10.1038/s41598-022-08213-0

[16] Malathi, K.; Ramana Murthy, K.V.; Bhikshapathi, D.V.R.N.; Kusum B. Physico-Chemical Characterization of Diclofenac and Rasagiline Salts and its Relationship for Development of Sublingual Drug Delivery Systems. Int. J. Pharm. Sci. Drug Res. 2021, 13, 60-66. https://doi.org/10.25004/IJPSDR.2021.130109

[17] Sa'adon, S.; Ansari, M.N.M.; Razak, S.I.A.; Anand, J.S.; Nayan, N.H.M.; Ismail, A.E.; Khan, M.U.A.; Haider, A. Preparation and Physicochemical Characterization of a Diclofenac Sodium-Dual Layer Polyvinyl Alcohol Patch. Polymers 2021, 13, 2459. https://doi.org/10.3390/polym13152459
https://doi.org/10.3390/polym13152459

[18] Maurin, J.K.; Plucinski, F.; Mazurek, A.P.; Fijalek, Z. The Usefulness of Simple X-ray Powder Diffraction Analysis for Counterfeit Control - The Viagra® example. J. Pharm. Biomed. Anal. 2007, 43, 1514-1518. https://doi.org/10.1016/j.jpba.2006.10.033
https://doi.org/10.1016/j.jpba.2006.10.033

[19] Jendrzejewska, I.; Zajdel, P.; Pietrasik, E.; Barsova, Z.; Goryczka, T. Application of X-ray Powder Diffraction and Differential Scanning Calorimetry for Identification of Counterfeit Drugs. Monatsh. Chem. 2018, 149, 977-985. https://doi.org/10.1007/s00706-018-2193-z
https://doi.org/10.1007/s00706-018-2193-z

[20] Caira, M.R. Current Applications of Powder X-Ray Dif-fraction in Drug Discovery and Development. Am. Pharm. Rev. 2014, 17,

54-58.

[21] Witkowski, M.R.; DeWitt, K. The Use of X-Ray Powder Diffraction (XRD) and Vibrational Spectroscopic Techniques in the Analysis of Suspect Pharmaceutical Products. Spectroscopy 2020, 35, 41-48.

[22] Derzhavna Farmakopeya Ukrayiny : v. 2. In Derzhavne pid-pryyemstvo «Ukrayins'kyy naukovyy farmakopeynyy tsentr yakosti likars'kykh zasobiv»; 2-e vyd. Kharkiv: Derzhavne pidpryyemstvo «Ukrayin s'kyy naukovyy farmakopeynyy tsentr yakosti likars'kykh zasobiv», 2014.

[23] Kraus, W.; Nolze, G. Powder Cell - a Program for the Representation and Manipulation of Crystal Structures and Calcula-tion of the Resulting X-Ray Powder Patterns. J. Appl. Crystall. 1996, 29, 301-303. https://doi.org/10.1107/S0021889895014920
https://doi.org/10.1107/S0021889895014920

[24] Crystallography Open Database. http://crystallography.net/cod/ (accessed 2022-11-17).

[25] Zhu, G.; Xiao, Z.; Zhu, G.; Rujunzhou, Niu Y. Encapsulation of L-Menthol in Hydroxypropyl-β-Cyclodextrin and Release Characteristics of The Inclusion Complex. Pol. J. Chem. Technol. 2016, 18, 110-116. https://doi.org/10.1515/pjct-2016-0056
https://doi.org/10.1515/pjct-2016-0056

[26] Younes, H.A.; Khaled, R.; Mahmoud, H.M.; Nassar, H.F.; Abdelrahman, M.M.; Abo El-Ela, F.I.; Taha, M. Computational and Experimental Studies on the Efficient Removal of Diclofenac from Water Using ZnFe-Layered Double Hydroxide as an Environmen-tally Benign Absorbent. J. Taiwan Inst. Chem. Eng. 2019, 102, 297-311. https://doi.org/10.1016/j.jtice.2019.06.018
https://doi.org/10.1016/j.jtice.2019.06.018

[27] Paczkowska, M.; Wiergowska, G.; Miklaszewski, A.; Krause, A.; Mroczkowka, M.; Zalewski, P.; Cielecka-Piontek, J. The Analysis of the Physicochemical Properties of Benzocaine Polymorphs. Molecules 2018, 23, 1737. https://doi.org/10.3390/molecules23071737
https://doi.org/10.3390/molecules23071737