Alginate/κ-Carrageenan Microspheres and their Application for Protein Drugs Controlled Release

Iryna Kolesnyk, Victoriia Konovalova and Anatoliy Burban
Affiliation: 
National University of Kiev-Mohyla Academy, 2, Skovoroda str., 04655 Kiev, Ukraine; i_kolesnik@yahoo.com
DOI: 
https://doi.org/10.23939/chcht09.04.485
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Abstract: 
pH-Responsive microspheres were prepared and their feasibility as potential carriers for oral delivery of protein drugs was evaluated. The microspheres were prepared from the ionotropically-crosslinked mixture of sodium alginate and κ-carrageenan. The morphology and size of the microspheres were investigated. A model protein drug α-amylase was entrapped and in vitro drug release profiles were established. The preliminary investigation of the microspheres showed a consistent swelling pattern, high entrapment efficiency and sustained release profiles of the enzyme. All the results indicated that the alginate/κ-carrageenan microspheres could be potentially useful in drug delivery systems.
References: 

[1] Koyamatsu Y., Hirano T., Kakizawa Y. et al.: J. Control. Release, 2014, 173, 89.
https://doi.org/10.1016/j.jconrel.2013.10.035

[2] Bysell H., Mansson R., Hansson P. and Malmsten M.: Adv. Drug Deliv. Rev., 2011, 63, 1172.
https://doi.org/10.1016/j.addr.2011.08.005

[3] Bejugam N., Gayakwad S., Uddin A. and D'souza M.: J. Microencapsul., 2013, 30, 274.
https://doi.org/10.3109/02652048.2012.720724

[4] Liu L., Wu F., Ju X.-J. et al.: J. Colloid Interface Sci., 2013, 404, 85.
https://doi.org/10.1016/j.jcis.2013.04.044

[5] Xiaofen T., Wei Zh. and Xingxiang L.: Adv. Mater. Res., 2014, 860-868, 577.

[6] Duongthingoc D., George P., Katopo L. et al.: Food Chem., 2013, 141, 1787.
https://doi.org/10.1016/j.foodchem.2013.04.093

[7] British Pharmacopoeia Commission: British Pharmacopoeia, Vol. 3. TSO, 2013.

[8] Zheng J., Xie H., Yu W. et al.: Langmuir, 2012, 28, 13261.
https://doi.org/10.1021/la302615t

[9] George M. and Abraham T.: Int. J. Pharm., 2007, 335, 123.
https://doi.org/10.1016/j.ijpharm.2006.11.009

[10] Miralles G., Baudoin R., Dumas D. et al.: J. Biomed. Mater. Res., 2001, 57, 268.
https://doi.org/10.1002/1097-4636(200111)57:2<268::AID-JBM1167>3.0.CO;2-L

[11] Nayak A. and Pal D.: Int. J. Biol. Macromol., 2011, 49, 784.
https://doi.org/10.1016/j.ijbiomac.2011.07.013

[12] Fundueanu G., Constantin M. and Ascenzi P.: Acta Biomater., 2010, 6, 3899.
https://doi.org/10.1016/j.actbio.2010.04.026

[13] Chandy T., Mooradian D. and Rao G.: J. Appl. Polym. Sci., 1998, 70, 2143.
https://doi.org/10.1002/(SICI)1097-4628(19981212)70:11<2143::AID-APP7>3.0.CO;2-L

[14] Patil J., Kamalapur M. and Marapur S.: Digest J. Nanomater. Biostructures, 2010, 5, 241.

[15] Wandrey C., Bartkowiak A. and Harding S.: Materials for Encapsulation. Springer-Verlag, New York, 2010.
https://doi.org/10.1007/978-1-4419-1008-0_3

[16] Jao W.-Ch., Ho L.-Ch. and Chen Zh.-W.: J. China University SciTech., 2010, 42, 37.

[17] Atta A. and Abdel-Azim A.: Polym. Adv. Technol., 1998, 9, 340.
https://doi.org/10.1002/(SICI)1099-1581(199806)9:6<340::AID-PAT787>3.0.CO;2-F

[18] Rajesh R. and Rajesh H.: AAPS PharmSciTech, 2004, 5, 1.

[19] Mohamadnia Z., Jamshidi A. and Modeli H.: Iran. Polym. J., 2007, 16, 711.

[20] Krishnamootthy B. and Basu S.: Int. J. Pharm. & H. Care Res., 2013, 1, 96.

[21] Xiao Zh., Storms R. and Tsang A.: Anal. Biochem., 2006, 351, 146.
https://doi.org/10.1016/j.ab.2006.01.036

[22] Hua Sh., Ma H., Li X. et al.: Int. J. Biol. Macromol., 2010, 46, 517.
https://doi.org/10.1016/j.ijbiomac.2010.03.004