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Синтез, антибактеріальна, протигрибкова й антиоксидантна активність нових (бензо)імідазо[2,1-b][1,3]тіазинових четвертинних солей

Nataliia Slyvka1, Lesya Saliyeva1, Mariia Litvinchuk2, Alina Grozav3, Nina Yakovychuk3, Mykhailo Vovk2
Affiliation: 
1 Department of Organic and Pharmaceutical Chemistry, Lesya Ukrainka Volyn National University, 13 Volya Ave., Lutsk 43025, Ukraine 2 Department of Functional Heterocyclic Systems, Institute of Organic Chemistry of National Academy of Sciences of Ukraine, 5 Academician Kuharya St., Kyiv 02660, Ukraine 3 Department of Medical and Pharmaceutical Chemistry, Bukovinian State Medical University, Chernivtsi 58000, Ukraine slivka.natalia@vnu.edu.ua
DOI: 
https://doi.org/10.23939/chcht19.02.242
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Abstract: 
Реакція 6-гідрокси-6,7-дигідро-2Н-(бенз)імідазо[2,1-b][1,3]тіазинів з галогеновмісними ацетофенонами дала серію четвертинних солей 1-фенацил(4-хлорфенацил)-6-гідрокси-6,7-дигідро-5Н-бензо[4,5]імідазо[2,1-b][1,3]тіазинію броміди 4a-f, структура яких була чітко доведена методами 1H ЯМР, 13C ЯМР та хромато-мас-спектрометрії. Усі отримані сполуки були перевірені в експериментах in vitro на антибактеріальну, протигрибкову й антиоксидантну активність. Результати біоскринінгу показали, що 1-(4-хлорфенацил)-6-гідрокси-6,7-дигідро-5Н-бензо[4,5]імідазо[2,1-b][1,3]тіазинію бромід 4f демонструє найвищу антибактеріальну дію активність щодо штаму грампозитивних бактерій Staphylococcus aureus ATCC 25923 у концентрації 125 мкг/мл, а солі 4a, c, f щодо штамів грамнегативних бактерій Pseudomonas aeruginosa ATCC 27853 у концентрації 62,5 мкг/мл. Найкращий показник як інгібітора вільних радикалів продемонструвала сіль 4с на рівні 69,3%.
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