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Application of Ozone in Medicine

Slavcho Rakovsky and Gennady Zaikov
DOI: 
https://doi.org/10.23939/chcht03.03.237
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Keywords:

Abstract: 
This review deals with the application of ozone in medicine, its effects on the human organism and its use as a therapeutic approach and sterilizing agent. A particular attention is paid to the therapeutic properties, therapeutic dosage and scope of application. Some mechanisms of the ozone effect at exposure on different organs and systems in human body are also considered. Ozone toxicity is reviewed. The ozone use as a sterilizing agent in the pharmaceutical industry and cosmetics, as well as in the food processing industry is discussed.
References: 

[1] Binz C.: Real Encyclopedi der gesamten Helkunder Bd. 18, S. 189, Berlin und Wien 1898.

[2] Brinkmson S. and Lambert K.: Nature, 1958, 181, 1202.
https://doi.org/10.1038/1811202a0

[3] Shepatlnovskii V. and Mikashinovich Z.: II Vsesousnaya konferencia "Poluchenie I primenenie ozona". Moskwa 1991, 157.

[4] Schmitthaeusler R.: Pat. EP0261032. Publ. March 23, 1988.

[5] Carpendiae M. and Freeberg J.: J. Clin. Gastroenterol., 1993, 17, 142.
https://doi.org/10.1097/00004836-199309000-00010

[6] Belianin I. and Shmelev E.: Ter. Arkh., 1994, 66, 29.

[7] Sato H.: Exp. Anim., 1990, 39, 223.
https://doi.org/10.1097/00006199-199007000-00010

[8] Grits N. and Formichev A.: Microbiologiya, 1990, 59, 831.

[9] Heindh L.: Zentralbl. Hyg. Unwelmed., 1993, 194, 464.

[10] Ancowski S.: Complement Inflammation, 1990, 7, 57.
https://doi.org/10.1159/000463129

[11] Kontorshtikova K. and Andreeva N.: II Vsesousnaya konferencia "Poluchenie I primenenie ozona". Moskwa 1991, 157.

[12] Aliev M. and Ioffe L.: ibid, 161.

[13] Krivatkin S.: ibid, 156.

[14] Gloor M. and Lipphardt B.: Zh. Hautkr., 1976, 51, 97.

[15] Sweet F.: Science, 1980, 209, 931.
https://doi.org/10.1126/science.7403859

[16] Richter A.: J. Toxicol. Environ. Health, 1988, 25, 383.

[17] Uehara K.: Pat. EP0601891. Publ. June 15, 1994.

[18] Burleson G. and Murray T.: Appl. Microbiol., 1975, 29, 340.
https://doi.org/10.1128/AEM.29.3.340-344.1975

[19] Karzenelson E., Koerner G. And Biederman N.: Appl. Environ. Microbiol., 1979, 37, 715.
https://doi.org/10.1128/AEM.37.4.715-718.1979

[20] Vaughn J. and Chen Y.: Appl. Environ. Microbiol., 1987, 53, 2218.
https://doi.org/10.1128/AEM.53.9.2218-2221.1987

[21] Lee R.: Semin. Oncol., 1974, 1, 254.

[22] Rokitansky O.: Hospitalis, 1982, 52, 643.

[23] Storczynski J. and Antoszewski Z.: Pol. Tyd. Lek., 1992, 47, 964.

[24] Turzynski B. and Stroszynski J.: Pol. Tyd. Lek., 1991, 46, 700.

[25] Rilling S.: "Ozone" Sci. Eng. Intern., 1985, 7, 257.
https://doi.org/10.1080/01919518508552307

[26] Schulzs S.: Lab. Anim., 1986, 20, 41.
https://doi.org/10.1258/002367786781062160

[27] Kramer F.: Erfahrungsheilkunde, 1975, 24, 120.

[28] Kramer F.: Ozonachrichten, 1983, 2, 65.
https://doi.org/10.3109/10520298309066755

[29] Turk R.: Erfahrungsheilkunde, 1976, 25, 177.

[30] Pribluda S.: Semana Med., 1963, 123, 10.

[31] Wolff H.: Das medizinische Ozon. vfm Publications, Heilderberg 1979.

[32] Payr E.: Munchner Medizinische Wochenschrift, 1935, 82, 220.

[33] Salzer N., Metka M. and Shonbauer M.: Erhfahrungsheilkunde, 1983, 32, 9731.

[34] Werkmeister H.: Erfahrungsheilkunde, 1976, 25, 180.

[35] Dorstewitz H.: Kongres-bericht der artztlichen geselltschafen fur ozontherapie, Baden-Baden 1981.

[36] Stadlaender S.: Erfahrungsheilkunde, 1981, 30, 277.

[37] Rokitansky O.: Hospitalis, 1982, 52, 711.

[38] Rotter M. and Mittermayer H.: Wien Klin. Wochenschr., 1974, 86, 776.

[39] Washuttl J.: Erfahrungsheilkunde, 1979, 28, 811; 1983, 32, 815.

[40] Washuttl J., Viebahn R.: "Ozone" Sci. Eng. Intern., 1989, 11, 411.
https://doi.org/10.1080/01919518908552450

[41] Sweet F.: Science, 1980, 202, 931.
https://doi.org/10.1126/science.7403859

[42] Viebahn R. and Steiner I.: "Ozone" Sci. Eng. Intern., 1989, 12, 65.
https://doi.org/10.1080/01919519008552455

[43] Anbrinkm, R. and Lamberts H.: Nature, 1958, 181, 1202.
https://doi.org/10.1038/1811202a0

[44] Chow C. and Mustafa M.: Environ. Physiol. Biochem., 1975, 5, 142.

[45] Brickley R., Hackney J. and Clark K.: Arch. Environ. Health, 1975, 30, 40.
https://doi.org/10.1080/00039896.1975.10666631

[46] Goldstein B.: Arch. Environ. Health, 1975, 26, 279.
https://doi.org/10.1088/0031-9112/26/6/047

[47] Vender R.: Toxicol. Ind. Health, 1994, 10, 53.
https://doi.org/10.1177/074823379401000104

[48] Pryor W.: Chem. Biol. Interact., 1991, 79, 41.

[49] Lamberts H. and Veninga T.: Lancet, 1964, 1, 133.

[50] Schulz E., Moore G. and Calabrese E.: Bull. Environ. Contam. Toxicol., 1981, 26, 273.
https://doi.org/10.1007/BF01622090

[51] Chow C. and Tappel A.: Arh. Environ. Health, 1973, 26, 205.
https://doi.org/10.1080/00039896.1973.10666257

[52] Sato S. and Kawakami M.: Am. Rev. Resp. Dis., 1976, 113, 809.

[53] Chow C. and Kaneko J.: Environ. Res., 1979, 19, 49.
https://doi.org/10.1016/0013-9351(79)90033-1

[54] Chan P. and Kindya R.: J. Biol.Chem., 1977, 252, 8537.
https://doi.org/10.1016/S0021-9258(19)75253-3

[55] Savino A. and Peterson M.: Environ. Res., 1978, 15, 65.
https://doi.org/10.1016/0013-9351(78)90079-8

[56] Canada A. and Airriess G.: Nutrit. Res., 1987, 7, 797.
https://doi.org/10.1016/S0271-5317(87)80110-0

[57] Myrphy S. and Davis H.: Toxicol. Appl. Pharmacol., 1964, 6, 528.

[58] Giri S. and Hollinger M.: Environ. Res., 1980, 21, 467.
https://doi.org/10.1016/0013-9351(80)90051-1

[59] Veninga T. and Wagenaar J.: Environ. Health Perspect., 1981, 39, 153.
https://doi.org/10.1289/ehp.8139153

[60] Shimasaki H. and Takatori T.: Biochem. Biophys. Res. Comm., 1976, 68, 1256.
https://doi.org/10.1016/0006-291X(76)90332-6

[61] Jankovski S. and Doroszkiewicz W.: Complement Inflammation, 1990, 7, 57.
https://doi.org/10.1159/000463129

[62] Jegier Z.: J. Am. Ing. Hyg. Assoc., 1974, 137, 329.

[63] Kleinfeld M. and Giel P.: Am. J. Med. Sci., 1956, 231, 638.
https://doi.org/10.1097/00000441-195606000-00004

[64] Laperwerff J.: Aerospace Med., 1963, 34, 479.
https://doi.org/10.1080/00325481.1963.11694911

[65] Trams E. and Lauter C.: Arch. Environ. Health., 1972, 24, 153.
https://doi.org/10.1080/00039896.1972.10666065

[66] Berney W., Dyer R.: US Environ. Prot. Agency OFF Res. Dev., EPA, 1976, 1, PB-264, 233, 555.

[67] Hackney J.: From Gov. Rep. Announce Index (U.S.), 1977, 77, 98.

[68] Takanashi Y. and MiuraT.: J. Toxicol. Environ. Health, 1985, 15, 855.

[69] Zelac R. and Cromroy H.: Environ. Res., 1971, 4, 262; 325.
https://doi.org/10.1016/0013-9351(71)90032-6

[70] Vaughan T. and Moorman W.: Toxicol. Appl. Pharmacol., 1971, 20, 404.
https://doi.org/10.1016/0041-008X(71)90283-3

[71] Uchiyama I.: Environ. Res., 1989, 48, 78.
https://doi.org/10.1007/978-1-349-11170-1_3

[72] Fairchild E. and Grahm S.: Toxicol. Appl. Pharmacol., 1964, 6, 607.

[73] Gordon T., Taylor B. and Amdur M.: Arch. Environ. Health, 1981, 36, 284.
https://doi.org/10.1080/00039896.1981.10667639

[74] Eskerv M. and Scheuchenzuber M.: Environ. Res., 1976, 40, 274.
https://doi.org/10.1016/0043-1648(76)90105-8

[75] Criege R.: Rec. Chem. Prog., 1957, 18, 111.

[76] Menzel D.: Adv. Mod. Environ. Toxicol., 1982, 5, 183.

[77] Chow C. and Hussain M.: Exprl. Path., 1976, 25, 182.
https://doi.org/10.1016/0014-4800(76)90028-9

[78] Last J. and Greenberg D.: Toxicol. Appl. Pharm., 1979, 51, 247.
https://doi.org/10.1016/0041-008X(79)90467-8

[79] Hussain Z. and Goss C.: Life Sci., 1976, 18, 897.
https://doi.org/10.1016/0024-3205(76)90406-9

[80] Veninga T.: Environ. Health Perspect., 1981, 39, 153.
https://doi.org/10.1289/ehp.8139153

[81] Chow C. and Goss C.: J.Toxicol. Environ. Health, 1977, 3, 877.

[82] Saymor W.: Arch. Environ. Health, 1974, 29, 164.
https://doi.org/10.1080/00039896.1974.10666556

[83] Mohammad M. and Anthany D.: J. Chest, 1974, 66, 21.
https://doi.org/10.1378/chest.66.2.21-a

[84] Summer W.: Process Biochem., 1976, 11, 26.

[85] Plopper C.: Toxicol. Appl. Pharmacol., 1994, 121, 124.

[86] Debral L. and Kimberly E.: Environ. Health Perspect. Suppl., 1994, 102, 61.

[87] Kelly F.: Hum.Exp. Toxicol., 1994, 13, 407.
https://doi.org/10.1177/096032719401300607

[88] Drechsler P. and Deborah M.: Exp. Geront., 1995, 30, 65.
https://doi.org/10.1016/0531-5565(94)00051-4

[89] Miller F., Oventon J. and Kaskot R.: Tox. Appl. Pharm., 1985, 79, 11.

[90] Stock T. and Kotchmar D.: J. Air Pollut. Contr. Assoc., 1985, 35, 1266.
https://doi.org/10.1080/00022470.1985.10466029

[91] Dillar C. and Urribarri N.: Arch. Environ. Health, 1972, 25, 426.
https://doi.org/10.1080/00039896.1972.10666198

[92] Mohammad M. and Anthony D.: J. Lab. Clin. Med., 1973, 82, 357.

[93] Peister A.: Presse Term. Clim., 1977, 1, 58.

[94] Godstein B. and Belchum O.: Toxicol. Appl. Pharmacol., 1974, 27, 330.

[95] Elaine S. and Dziedzic D.: Toxicol. Lett., 1990, 51, 125.
https://doi.org/10.1016/0378-4274(90)90206-2

[96] Schesinger R. and Driscoll K.: J. Toxicol. Environ. Health, 1987, 20, 125.

[97] Abraham W. and Sielezak W.: Eur. J. Respir. Dis., 1986, 68, 114.

[98] Foster W., Costa D. and Langenbak E.: J. Appl. Physiol., 1987, 63, 996.
https://doi.org/10.1152/jappl.1987.63.3.996

[99] Boorman G., Schwartz L. and Dungworth D.: Lab. Invest., 1980, 43, 108.

[100] Nikula K., Wilson D. and Giri S.: Am. J. Pathol., 1988, 131, 373.

[101] Harkema J., Plopper C. and Hyde D.: Am. J. Pathol., 1987, 128, 44.

[102] Kirkpatrik J. and Henderson R.: Exp. Lung. Res. 1989, 15, 1.

[103] Schlesinger R.: J. Toxicol. Environ. Health, 1987, 21, 27.
https://doi.org/10.2307/2214915

[104] Lum H. and Plopper D.: Exp. Lung Res., 1983, 5, 61.
https://doi.org/10.3109/01902148309061505

[105] Foster M.: J. Appl. Physiol., 1993, 75, 5.

[106] Driscoll K. and Schlesinger R.: Toxicol. Appl. Pharmacol., 1988, 93, 312.
https://doi.org/10.1016/0041-008X(88)90131-7

[107] Kimura A. and Goldstein E.: J. Infect. Dic., 1981, 143, 247.
https://doi.org/10.1093/infdis/143.2.247

[108] Sherwood R. and Goldstein E.: Environ. Res., 1986, 41, 378.
https://doi.org/10.1016/S0013-9351(86)80133-5

[109] Bleavins M. and White H.: Toxicologist, 1987, 7, 129.

[110] Bleavins M. and Dziedzic D.: Toxicologist, 1988, 8, 198.

[111] Sell S.: Immunology, immunopathology and immunity. Elsevier, New York 1987.

[112] Aranyi C., Vana S. and Thomas P.: J.Toxicol. Environ. Health, 1983, 12, 55.
https://doi.org/10.1080/15287398309530407

[113] Eskew M., Scheuchenzuber W. and Scholz R.: Environ. Res., 1986, 40, 274.
https://doi.org/10.1016/S0013-9351(86)80103-7

[114] Amoruso M. and With G.: Life Sci., 1981, 28, 2215.
https://doi.org/10.1016/0024-3205(81)90572-5

[115] Nikola K., Wilson D., Dungworth D. and Plopper C.: Toxicol. Appl. Pharmacol., 1989, 93, 394.
https://doi.org/10.1016/0041-008X(88)90042-7

[116] Tankersley C.: Toxicol. Lett., 1994, 72, 279.
https://doi.org/10.1016/0378-4274(94)90039-6

[117] Stephens R., Sloan M. and Reeman G.: Am. J. Pathol., 1973, 74, 31.

[118] Evans M. and Dekker N.: Exp. Mol. Phatol., 1985, 42, 366.
https://doi.org/10.1016/0014-4800(85)90086-3

[119] Plopper C., Chow C. and Dunworth D.: Exp. Mol. Pathol., 1978, 29, 400.
https://doi.org/10.1016/0014-4800(78)90081-3

[120] Nikula K., Wilson D., Dungworth D. and Plopper C.: Am. J. Pathol., 1988, 131, 373.

[121] Hussain M. and Cross C.: Life Sci., 1976, 18, 897; 904.
https://doi.org/10.1088/0032-1028/18/12/003

[122] Last J. and Greenberg D.: Toxicol. Appl. Pharmacol., 1979, 51, 257.
https://doi.org/10.1016/0041-008X(79)90467-8

[123] Fukase O. and Hashimoto K.: Nippon Eiseigaku Zassi., 1982, 37, 694.
https://doi.org/10.1265/jjh.37.694

[124] Better A.: Pat. EP 0222309. Publ. May 20, 1987.

[125] Bothner J.: Pat. DE 3.806.203. Publ. September 07, 1989.

[126] Faddis C.: Pat. US 5.266.275. Publ. November 30, 1993.

[127] Kuvakina N.: Pat. RU 2.289.812. Publ. December 20, 2006.

[128] Gal G.: Int. J. Artifical Organs, 1992, 15, 461.
https://doi.org/10.1177/039139889201500803

[129] Hiromichi M.: Pat. JP 05.329.196. Publ. February 18, 1993.

[130] Geabelein K.: Seifen, Oile, Fette, Wasche, 1986, 112, 1718.