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Hybrid antioxidants

Elena Burlakova, Elena Molochkina and Grygoriy Nikiforov
DOI: 
https://doi.org/10.23939/chcht02.03.163
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Abstract: 
The article is a review of the data on synthesis and physiological activity of hybrid antioxidants. The introduction offers an explanation to the fact why, in some cases, it is necessary to add drug molecules with fragments responsible for various properties and aimed at various targets. A large group of hybrid antioxidants comprise stable nitroxyl radicals that behave as antioxidants in free-radical reactions of oxidation. Compounds of this type were synthesized extensively to form a group of antitumor agents. As a rule, the specific (antitumor) activity retained or even increased as compared with the initial compounds (without nitroxyl radicals); the toxicity decreased 5 to 10 times, which made it possible to apply the drug in considerably higher concentrations. There are reported data on nitroxyl derivatives of anthracycline antibiotics, antimetabolites, alkyl ting agents, and the recent results on platinum complexes with nitroxyl fragments. Much attention is given to hindered phenols with “buoyancy” properties, particularly, to biochemical effects, making them promising agents to treat Alzheimer’s disease.
References: 

[1] Аristarkhova S., Arkhipova G., Burlakova E. et al.: Dokl. Akad. Nauk SSSR, 1976, 227, 215.

[2] Burlakova E., Arkhipova G., Dzhalyabova M. et al.: Bioph. Biochem. Inform. Transfer in Recogn. & Aging, 1979, 583.
https://doi.org/10.1007/978-1-4899-5330-8_52

[3] Burlakova Е.: 4th Int. Congr. Biophys., Moskva 1972, 67.

[4] Burlakova E., Dzhalyabova M., Koblyakov V. et al.: Dokl. Akad. Nauk SSSR, 1978, 241, 477.

[5] Chernyavskaya L., Arkhipova G. and Burlakova E.: Neurokhimia, 1989, 8, 249.

[6] Kalmykova V. and Burlakova E.: Sov. Med., 1982, 4, 3.

[7] Burlakova E., Palmina N.: Vestnik Akademii Med. Nauk SSSR, 1982, 3, 74.

[8] Nikiforov G., Belostotskaya I. and Volyeva V.: Nаuchnyi Vestnik Tyumen. Med. Akad., 2003, 1, 50.

[9] Konovalova N., Bogdanov G., Miller V. et al.: Dokl. Akad. Nauk SSSR, 1964, 157, 707.

[10] Burlakova E., Gaintseva V., Slepukhina L. et al.: Dokl. Akad. Nauk SSSR, 1965, 4, 934.

[11] Shapiro A., Kropacheva A., Suskina V. et al.: Izv. Akad. Nauk SSSR, Ser. Khim., 1971, 4, 864.

[12] Коnovalova N.: Khim. Fiz., 1991, 6, 861.

[13] Emanuel N., Konovalova N., Povarov L. et al.: A. c. 977462 SSSR//BI, 1980.

[14] Emanuel N., Konovalova N. and Diatchkovskaya R.:.Neoplasma, 1985, 32, 285.

[15] Emanuel N., Zhdanov R., Konovalova N. et al.: Voprosy oncologii, 1980, 36, 54.

[16] Sosnovsky J. and Shu Wen Li.: Drug Future, 1985, 3, 211.

[17] Seminara P., Franchi F., Konovalova N. et al.: Acta Haematol., 2001, 105, 77.
https://doi.org/10.1159/000046538

[18] Emanuel N., Rozenberg A., Golubev V. et al.: Aktualnye Problemy Eksperimentalnoi Khemoterapii Opuholej. Chernogolovka 1987, 5.

[19] Sen' V., Rukina N., Tkachev V. et al.: Izv. Akad. Nauk, Ser. Khim., 2000, 9,1624.

[20] Sen' V.., Tkachev V., Volkova L. et al.: Izv. Akad. Nauk, Ser. Khim., 2003, 2, 403.

[21] Sen' V., Golubev V., Rukina N. et al.: Pat. RU 2103274 C1, 1998.

[22] Behl C.: J. Biol. Chem., 1996, 271, 26482.
https://doi.org/10.1074/jbc.271.43.26482

[23] Nitsh R., Blusztajns J., Pittas A. et al.: Proc. Natl. Acad. Sci. USA, 1992, 89, 1671.

[24] Zafrilla P., Mulero J., Xandri J.M. et al.: Curr. Med. Chem., 2006, 13, 1075.
https://doi.org/10.2174/092986706776360978

[25] Frank B. and Gupta S. : Ann. Clin. Psychiatr., 2005, 17, 269.
https://doi.org/10.1080/10401230500296428

[26] Moreira P., Honda K., Liu Q. et al.: Curr. Alzheimer Res., 2005, 2, 403.
https://doi.org/10.2174/156720505774330537

[27] Mariani E., Polidori M., Cherubini A. et al.: J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci., 2005, 827, 65.
https://doi.org/10.1016/j.jchromb.2005.04.023

[28] Moreira P., Smith M., Zhu X. et al.: Drug News Perspect., 2005, 18, 13.
https://doi.org/10.1358/dnp.2005.18.1.877164

[29] Irizarry M.: NeuroRx., 2004, 1, 226.
https://doi.org/10.1602/neurorx.1.2.226

[30] Perevozkina M., Storozhok N. and Nikiforov G.: Biomed. Khim., 2005, 51, 413.

[31] Braginskaia F., Zorina O., Molochkina E. et al.: Izv. Akad. Nauk SSSR, Biol., 1992, 5, 690.

[32] Braginskaya F., Molochkina E., Zorina O. et al.: [in:] Becker R. and Giacobini E. (eds.), Alzheimer Disease: From Molecular Biology to Therapy. Birkhauser-Boston 1996, 337.
https://doi.org/10.1007/978-1-4612-4116-4_50

[33] Ozerova I., Molochkina E. and Burlakova E.: Advances in Gerontology, 2001, 6, 30.

[34] Molochkina E., Ozerova I. and Burlakova E.: Free Rad. Biol. Med., 2002, 33, 229.

[35] Amitai G., Rachaman E., Adani R. et al.: [in:] Becker R. and Giacobini E. (eds.), Alzheimer Disease: From Molecular Biology to Therapy. Birkhauser-Boston 1996.

[36] Buchet R. and Piku S.: Acta Biochimica Polonica, 2000, 47, 725.
https://doi.org/10.18388/abp.2000_3991

[37] Prasad M., Lovell M., Yatin M. et al.: Neurochem. Res., 1998, 23, 81.
https://doi.org/10.1023/A:1022457605436

[38] Wells K., Farookui A., Liss L. et al.: Neurochem. Res., 1995, 20, 1329.
https://doi.org/10.1007/BF00992508

[39] Soderberg M., Edlund C., Kristensson K. et al.: Lipids, 1991, 26, 421.
https://doi.org/10.1007/BF02536067

[40] Pettegrew J., Panchalingam K., Hamilton R. et al.: Neurochem. Res., 2001, 7, 771.
https://doi.org/10.1023/A:1011603916962

[41] Soderberg M., Edlund C., Alafuzoff I. et al.: J. Neurochem., 1992, 5, 1646.
https://doi.org/10.1111/j.1471-4159.1992.tb10994.x

[42] Nitsch R., Blusztajn J., Pittas A. et al.: Proc. Natl. Acad. Sci. USA, 1992, 89, 1671.
https://doi.org/10.1073/pnas.89.5.1671

[43] Wells K., Farookui A., Liss L. et al.: Neurochem. Res., 1995, 20, 1329.
https://doi.org/10.1007/BF00992508

[44] Markesbery W., Leung P. and Butterfield D.: J. Neurol. Sci., 1980, 45, 323.
https://doi.org/10.1016/0022-510X(80)90175-6

[45] Zubenko G., Kopp U., Seto T. et al.: Psychopharmacology (Berl.), 1999, 145, 175.
https://doi.org/10.1007/s002130051046

[46] Kozubski W., Swiderek M., Kloszewska I. et al.: Neurol. Neurochir. Pol., 1999, 33, 1275.

[47] Muller W., Kirsch C. and Eckert G.: Biochem. Soc. Trans., 2001, 29, 617.
https://doi.org/10.1042/bst0290617

[48] Braginskaya F., Zorina O., Pal'mina N. et al.: Neurosci. Behav. Physiol., 2001, 31, 457.
https://doi.org/10.1023/A:1010405115973

[49] Simons M., Keller P., De Strooper B. et al.: Proc. Natl. Acad. Sci. USA, 1998, 95, 6460.
https://doi.org/10.1073/pnas.95.11.6460

[50] Eckert G., Kirsch C. and Muller W.: J. Nutr. Health Aging, 2003, 7, 18.

[51] Raffaï R. and Weisgraber K.: J. Lipid Res., 2003, 44, 1423.
https://doi.org/10.1194/jlr.R300007-JLR200

[52] Michikawa M.: Mol. Neurobiol., 2003, 1, 1.