1. JCCT
  2. Ch&ChT Vol. 19, No. 3, 2025
  3. Obtaining Biologically Active Compounds by Extraction of Valerian Roots

Obtaining Biologically Active Compounds by Extraction of Valerian Roots

×

Error message

  • Deprecated function: Unparenthesized `a ? b : c ? d : e` is deprecated. Use either `(a ? b : c) ? d : e` or `a ? b : (c ? d : e)` in include_once() (line 1439 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Array and string offset access syntax with curly braces is deprecated in include_once() (line 3557 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Unparenthesized `a ? b : c ? d : e` is deprecated. Use either `(a ? b : c) ? d : e` or `a ? b : (c ? d : e)` in include_once() (line 1439 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Array and string offset access syntax with curly braces is deprecated in include_once() (line 3557 of /home/science2016/public_html/includes/bootstrap.inc).
Vasyl Dyachok1, Oksana Ivankiv2, Iruna Dіachok2
Affiliation: 
1 Lviv Polytechnic National University, 12 S. Bandery St., Lviv 79013, Ukraine 2 Danylo Halytsky Lviv National Medical University, 69 Pekarska St., Lviv 79010, Ukraine dyachokvasil@gmail.com
DOI: 
https://doi.org/10.23939/chcht19.03.520
AttachmentSize
PDF icon full_text.pdf268.47 KB
Keywords: 
isovaleric acid
extraction
cellular volume
intercellular volume
ion exchange
equilibrium
Abstract: 
An effective method of obtaining biologically active substances from plant raw materials without changing their optical isomerism is extraction. The investigation results of achieving equilibrium conditions for isovaleric acid extraction from valerian roots and rhizomes are presented. The effect of the isovaleric acid chemical structure and extractant nature on achieving equilibrium conditions is shown. Extraction of valerian roots and rhizomes with 70% ethyl alcohol allows a traditional extraction process, i.e., an equilibrium straight line of Ср=С1р type. If desalinated water is used as an extractant, an unconventional case of Ср≠С1р will arise, complicated by the solvation of isovaleric acid molecules and, consequently, the corresponding equilibrium conditions. The possibility of using ion exchange to isolate isovaleric acid from the polyextract of biologically active compounds was investigated. A technological scheme for obtaining isovaleric acid using ion technologies was proposed. Isovaleric acid was identified by gas chromatography.
References: 

[1] Aman, D. Introductory chapter; Plant extracts, 2019. https://doi.org/10.5772/intechopen.85493
https://doi.org/10.5772/intechopen.85493

[2] Swamy, M.; Akhtar, M. Natural Bio-active Compounds, 2; Chemistry, Pharmacology and Health Care Practices, 2019. https://doi.org/10.1007/978-981-13-7205-6
https://doi.org/10.1007/978-981-13-7205-6

[3] Chernykh, V.; Avramenko, N. Farmatsevtychna entsyklopediia; MORION: Kyiv, 2016.

[4] Georgievsky, V.; Koneev, F. Technologia i Standardizacia Lekarstv; RIREG, 2000.

[5] Vargas-Cortez, T.; Jacobo-Velázquez, D.; Benavides, J. Therapeutic Plants with Immunoregulatory Activity and Their Applications: A Scientific Vision of Traditional Medicine in Times of COVID-19. J. Med. Food. 2022, 12, 1074-1085. https://doi.org/10.1089/jmf.2022.0038
https://doi.org/10.1089/jmf.2022.0038

[6] Miroshnichenko, D.; Zhylina, M.; Shmeltser, K. Modern Use of Biochar in Various Technologies and Industries. A Review. Chem. Chem. Technol. 2024, 18, 232-243. https://doi.org/10.23939/chcht18.02.232
https://doi.org/10.23939/chcht18.02.232

[7] Semenyuk, N.; Dudok, G.; Skorokhoda, V. Hydrogels in Biomedicine: Granular Controlled Release Systems Based on 2-Hydroxyethyl Methacrylate Copolymers. A Review. Chem. Chem. Technol. 2024, 18, 143-156. https://doi.org/10.23939/chcht18.02.143
https://doi.org/10.23939/chcht18.02.143

[8] Zaczynska, E.; Czarny, A.; Karpenko, O.; Vasylyuk, S.; Monka, N.; Stadnytska, N.; Fizer, L.; Komarovska-Porokhnyavets, O.; Jaranowski, M.; Lubenets, V.; et al. Оbtaining and Determining Antiviral and Antibacterial Activity of s-Esters of 4-r-Aminobenzenethiosulfonic Acid. Chem. Chem. Technol. 2023, 17, 315-324. https://doi.org/10.23939/chcht17.02.315
https://doi.org/10.23939/chcht17.02.315

[9] Dyachok, I.; Pinyazhko, O.; Ivankiv, O. Dynamics of Exception of Organic Acids from Mixture of Medical Vegetable Raw Material. ScienceRise: Pharmaceutical Science 2018, 3, 37-42. https://doi.org/10.15587/2519-4852.2018.135874
https://doi.org/10.15587/2519-4852.2018.135874

[10] Dyachok, I.; Pinyashko, O. The Development of Quantitative Determination Method of Organic Acids in Complex Poly Herbal Extraction. Current Issues in Pharmacy and Medicine: Science and Practice 2016, 2, 52-57. https://doi.org/10.14739/2409-2932.2016.2.71129
https://doi.org/10.14739/2409-2932.2016.2.71129

[11] Dyachok, V.; Marakhovska, A.; Marakhovska, S. Application of Liquid Extraction for Treatment of Wastewater from Edible Oils Production. Chem. Chem. Technol. 2018, 12, 114-149. https://doi.org/10.23939/chcht12.01.114
https://doi.org/10.23939/chcht12.01.114

[12] Dyachok, V.; Huhlych, S.; Yatchyshyn, Y.; Zaporochets, Y.; Katysheva, V. About the Problem of Biological Processes Complicated by Mass Transfer. Chem. Chem. Technol. 2017, 11, 111-116. https://doi.org/10.23939/chcht11.01.111
https://doi.org/10.23939/chcht11.01.111

[13] Pavliuk, I.; Dyachok, V.; Novikov, V.; Ilkiv, N. Kinetics of Biologically Active Compound Extraction from Hops Strobiles Extraction Cake. Chem. Chem. Technol. 2017, 11, 487-491. https://doi.org/10.23939/chcht11.04.487
https://doi.org/10.23939/chcht11.04.487

[14] Akhtar, I.; Javad, S.; Yousaf, Z.; Iqbal, S.; Jabeen, K. Microwave Assisted Extraction of Phytochemicals an Efficient and Modern Approach for Botanicals and Pharmaceuticals. Pakistan journal of pharmaceutical sciences 2019, 32, 223-230.