Synthesis and Thermodynamic Parameters of Phase Transitions of 3-(1-R-5-Phenyl-1H-Pyrrol-2-yl)propanoic Acid Derivatives

Dmytro Shevchenko1, Yuriy Horak2, Nadiia Tyschenko3, Dariia Kichura4, Mykola Obushak2, Iryna Sobechko1

Affiliation:

1 Department of Physical, Analytical and General Chemistry, Institute of Chemistry and Chemical Technologies, Lviv Polytechnic National University, 12 S. Bandery St., Lviv 79013, Ukraine 2 Department of Organic Chemistry, Faculty of Chemistry, Ivan Franko National University of Lviv, 6 Kyryla and Mefodiya St., Lviv 79005, Ukraine 3 Department № 48 of Physics, Chemistry and Technology of Nanotextured Ceramics and Nanocomposite Materials, Frantsevich Institute for Problems of Materials Science, National Academy of Sciences of Ukraine, 3 Krzhizhanovskoho St., Kyiv 03142, Ukraine 4 Department of Organic Products Technology, Institute of Chemistry and Chemical Technologies, Lviv Polytechnic National University, 12 S. Bandery St., Lviv 79013, Ukraine dmytro.s.shevchenko@lpnu.ua

DOI:

https://doi.org/10.23939/chcht19.03.403

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Abstract:

A series of 3-(1-R-5-phenyl-1H-pyrrol-2-yl)propanoic acids (R = H, Ar, Alk, Hetaryl) was obtained via the reaction of 4,7-dioxo-7-phenylheptanoic acid with amines. The enthalpies of vaporization and fusion of eight compounds were experimentally determined using differential thermal and thermogravimetric methods of analysis for the first time. Based on the experimentally determined thermodynamic parameters of the melting process, an analytical method for calculating the enthalpy of fusion from the specific value of the entropy of fusion for substances with an arylpyrrole fragment is proposed. Calculating methods for the enthalpies of sublimation using the data of derivatographic studies are analyzed. Recalculation of the enthalpies of phase transitions to 298.15 K was performed.

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Synthesis and Thermodynamic Parameters of Phase Transitions of 3-(1-R-5-Phenyl-1H-Pyrrol-2-yl)propanoic Acid Derivatives

Keywords: