Error message

  • Deprecated function: Unparenthesized `a ? b : c ? d : e` is deprecated. Use either `(a ? b : c) ? d : e` or `a ? b : (c ? d : e)` in include_once() (line 1439 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Array and string offset access syntax with curly braces is deprecated in include_once() (line 3557 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Unparenthesized `a ? b : c ? d : e` is deprecated. Use either `(a ? b : c) ? d : e` or `a ? b : (c ? d : e)` in include_once() (line 1439 of /home/science2016/public_html/includes/bootstrap.inc).
  • Deprecated function: Array and string offset access syntax with curly braces is deprecated in include_once() (line 3557 of /home/science2016/public_html/includes/bootstrap.inc).

Synthesis, Structure and Properties of the Grafted Peptidomimetic Polymer Brushes Based on Poly(N-methacryloyl-L-proline)

Maria Tokareva1, Halyna Ohar1, Stanislav Tokarev1, Yuriy Stetsyshyn1
Affiliation: 
1 Lviv Polytechnic National University, 12, S. Bandery Іt., 79013 Lviv, Ukraine Mariia.O.Tokarieva@lpnu.ua
DOI: 
https://doi.org/10.23939/chcht15.01.026
AttachmentSize
PDF icon full_text.pdf300.05 KB

Keywords:

Abstract: 
A new approach to synthesis at the aminated glass surface of novel biocompatible polymeric nanolayers consisting of poly(N-methacryloyl-L-proline) brushes has been developed. Formation of the polymer nanolayers has been realized in several stages. At the first stage, the glass surface has been modified by aminosilane (APTEC), afterwards monolayer of the peroxide-containing initiator (PI) based on pyromellitic acid has been tethered to this aminated surface. The immobilized PI has been used further for initiation of the grafting "from the surface" polymerization of N-methacryloyl-L-proline for obtaining of the peptidomimetic polymer brushes. Features of the reactions, as well as optimal conditions for performing the process are highlighted in this work. Presented here poly(N-methacryloyl-L-proline) grafted brush coatings are promising material for numerous applications in nanomedicine, especially for production of implants and systems of the controlled interaction with proteins and cells.
References: 

[1] Motornov M., Roiter Y., Tokarev I., Minko S.: Prog. Polym. Sci., 2010, 35, 174. https://doi.org/10.1016/j.progpolymsci.2009.10.004
[2] Tokarev I., Gopishetty V., Zhou J. et al.: Appl. Mater. Interfaces, 2009, 1, 532. https://doi.org/10.1021/am800251a
[3] Lee H., Pietrasik J., Sheiko S., Matyjaszewski K.: Prog. Polym. Sci., 2010, 35, 24. https://doi.org/10.1016/j.progpolymsci.2009.11.002
[4] Cole M., Voelcker N., Thissen H., Griesser H.: Biomaterials, 2009, 30, 1827. https://doi.org/10.1016/j.biomaterials.2008.12.026
[5] Chen T., Ferris R., Zhang J. et al.: Prog. Polym. Sci., 2010, 35, 94. https://doi.org/10.1016/j.progpolymsci.2009.11.004
[6] Synytska A., Svetushkina E., Puretskiy N. et al.: Soft Matter, 2010, 6, 5907. https://doi.org/10.1039/C0SM00414F
[7] Luzinov I., Minko S., Tsukruk V.: Soft Matter, 2008, 4, 714. https://doi.org/10.1039/B718999K
[8] Fournier D., Hoogenboom R., Thijs H. et al.: Macromolecules, 2007, 40, 915. https://doi.org/10.1021/ma062199r
[9] Chen G., Hoffman A.: Nature, 1995, 373, 49. https://doi.org/10.1038/373049a0
[10] Lee H., Pietrasik J., Matyjaszewski K.: Macromolecules, 2006, 39, 3914. https://doi.org/10.1021/ma060350r
[11] Zhang J., Peppas N.: Macromolecules, 2000, 33, 102. https://doi.org/10.1021/ma991398q
[12] Garcia A., Marquez M., Cai T. et al.: Langmuir, 2007, 23, 224. https://doi.org/10.1021/la061632n
[13] Burkert S., Bittrich E., Kuntzsch M. et al.: Langmuir, 2010, 26, 1786. https://doi.org/10.1021/la902505q
[14] Mori H., Kato I., Endo T.: Macromolecules, 2009, 42, 4985. https://doi.org/10.1021/ma900706s
[15] Mori H., Iwaya H., Nagai A., Endo T.: Chem. Commun., 2005, 38, 4872. https://doi.org/10.1039/B509212D
[16] Mori H., Iwaya H., Endo T.: React. Funct. Polym., 2007, 67, 916. https://doi.org/10.1016/j.reactfunctpolym.2007.05.016
[17] Mori H., Iwaya H., Endo T.: Macromol. Chem. Phys, 2007, 208, 1908. https://doi.org/10.1021/ma902002b
[18] Mori H., Kato I., Matsuyama M., Endo T.: Macromolecules , 2008, 41, 5604. https://doi.org/10.1021/ma800181h
[19] Sanda F., Endo T.: Macromol. Chem. Phys., 1999, 200, 2651. https://doi.org/10.1002/(SICI)1521-3935(19991201)200:12<2651::AID-MACP2651>3.0.CO;2-P
[20] Mori H., Endo T.: Macromol. Rapid Commun., 2012, 33, 1090. https://doi.org/10.1021/ma0509558
[21] Chung I., Britt P., Xie D. et al.: Chem. Commun., 2005, 28, 1046. https://doi.org/10.1039/B416591H
[22] Liu Z., Hu J., Sun J. et al.: J. Polym. Sci. A, 2010, 48, 3573. https://doi.org/10.1002/pola.24137
[23] Katakai R., Yoshida M., Hasegawa S. et al.: Macromolecules, 1996, 29, 1065. https://doi.org/10.1021/ma951094d
[24] Katakai R., Saito K., Sorimachi M et al.: Macromolecules, 1998, 31, 3383. https://doi.org/10.1021/ma971727j
[25] Raczkowska J., Ohar M., Stetsyshyn Y. et al.: Colloid. Surface B, 2014, 118, 270. https://doi.org/10.1016/j.colsurfb.2014.03.049
[26] Stetsyshyn Y., Raczkowska J., Budkowski A. et al.: Langmuir, 2016, 32, 11029. https://doi.org/10.1021/acs.langmuir.6b02946
[27] Raczkowska J., Stetsyshyn Y., Awsiuk K. et al.: Appl. Surf. Sci., 2017, 407, 546. https://doi.org/10.1016/j.apsusc.2017.03.001
[28] Riddick J.,. Bunger W, Sakano T., Weissenerger A.: Organic Solvents: Physical Properties and Methods of Purification. Wiley, New York 1986.
[29] Milas N., Surgenor D.: Am J. Chem. Soc, 1946, 68, 205. https://doi.org/10.1021/ja01206a017
[30] Bentolila A., Vlodavsky I., Ishai-Michaeli R. et al.: J. Med. Chem., 2000, 43, 2591. https://doi.org/10.1021/jm000089j
[31] Bayer O., Houben J., Muller E.: Methoden der organischen Chemie (Houben-Weyl), G. Thieme, Stuttgart, 1952, 8, 464.
[32] Wang X., Gan H., Zhang M., Sun T.: Langmuir, 2012, 28, 2791. https://doi.org/10.1021/la204143g
[33] Cassie A.: Discuss. Faraday Soc, 1948, 3, 11. https://doi.org/10.1039/DF9480300011
[34] Swain P., Lipowsky R.: Langmuir, 1998, 14, 6772. https://doi.org/10.1021/la980602k
[35] Bootsma G., Meyer F.: Surf. Sci, 1969, 14, 52. https://doi.org/10.1016/0039-6028(69)90045-4
[36] Voronov S., Varvarenko S.: Peroksydovani Makromolekuly na Mezhi Rozdilu Faz. Vyd-vo LPNU, Lviv 2011.