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Synthesis of 3S-Substituted Triazino[5,6-b]indoles and 4-Thiazolidinone-triazino[5,6-b]indole Hybrids with Antitumor Activity

Stefan Harkov, Dmytro Havrylyuk and Roman Lesyk
Affiliation: 
Danylo Halytsky Lviv National Medical University 69, Pekarska str, 79010 Lviv, Ukraine; dr_r_lesyk@org.lviv.net
DOI: 
https://doi.org/10.23939/chcht07.04.381
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Abstract: 
The synthesis and antitumor activity screening of 1,2,4-triazino[5,6-b]indoles based conjugates were performed. Reaction between 3-mercapto-1,2,4-triazino[5,6-b]indoles and several N-arylchloroacetamides yielded 3S-substituted 1,2,4-triazino[5,6-b]indoles. Based on 3-hydrazine-1,2,4-triazino[5,6-b]indoles the new 4-thiazolidinones have been synthesized. Seven synthesized compounds were tested for their anticancer activity in NCI60 cell lines.
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